ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system (NNCS) in rats with ulcerative colitis (UC).
methodsUC rat model was established by administering 4% dextran sulfate sodium. After 7 d, mild moxibustion, α7 nicotinic acetylcholine receptors (α7nAchRs) antagonist (α-bungarotoxin, α-BGT), vesicular acetylcholine transport inhibitor (vesamicol hydrochloride, VH) and organic cation transporters inhibitor (quinine, Qu) treatments were performed once daily for 7 d. Haematoxylin and eosin staining was used for morphological evaluation of colon tissues. Enzyme-linked immunosorbent assay (ELISA) was used to measure the protein expressions of interleukin-1β (IL-1β) and choline acetyltransferase (ChAT) in colon tissue. Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the mRNA expressions of IL-1β, carnosine acetyltransferase (CarAT), ChAT, and nuclear factor kappa-B p65 subunit (NF-κB p65) in colon tissue. Western blot was used to detect NF-κB p65 protein expression in colon tissue. Immunofluorescence was used to detect the expressions of neuronal acetylcholine (nAch) and non-neuronal acetylcholine (nnAch, released by NNCS) in colon tissue.
resultsMild moxibustion inhibited colon inflammation and repaired mucosal damage to the colon in UC rats. Meanwhile, mild moxibustion could downregulate the expressions of IL-1β, NF-κB p65 protein and mRNA (
conclusionsMild moxibustion can inhibite colon inflammation in UC rats, which is closely related to the release of acetylcholine by NNCS and its mediated mechanism of cholinergic anti-inflammation pathway.
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