Evidence map›Paper›PMID 40151120›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Efficacy of electro-acupuncture at "Weizhong" (BL40) on macrophage polarization in rats with injured lumbar multifidus.

Tian Yuan, B U He, Wang Tieshan, Yang Dongliang, Zhang Wei, Liu Tong, Zhang Li, Huo Zejun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tian YuanDepartment of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
B U HeDepartment of Acupuncture-Moxibustion and Tuina, the Second Affiliated Hospital of Baotou Medical College, Inner Mongolia Autonomous Region, Baotou 014030, China.
Wang TieshanBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Yang DongliangCangzhou Medical College, Cangzhou 061000, China.
Zhang WeiDepartment of Pathology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Inner Mongolia 014010, China.
Liu Tongthe Fifth College of Clinical Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, China.
Zhang LiDepartment of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
Huo ZejunDepartment of Chinese Medicine, Peking University 3rd Hospital, Beijing 100191, China.

Funding

Exosomes Arounding Acupoints Deliver miR-206 to Mediate Insulin - like Growth Factor 1/Phosphatidylinositol 3 - Kinase/Protein Kinase B Pathway and Regulate Muscle Satellite Cell Differentiation: Mechanism of Electroacupuncture in Promoting Rehabilization of Lumbar Multifidus Muscles Injury in Model Rats 82174482Major Program of Foundation of Inner Mongolia Autonomous Region: Study on the Eeffect of Pediatric Tuina Combined with Acupuncture on the Intestinal Microflora Structure in Children with Provisional Tic Disorder and its Therapeutic Mechanism 201802127Natural Science Foundation-funded Project: Regulation of Autophagy by Electroacupuncture at Weizhong Point on the Proliferation of Multifidus Muscle Satellite Cells 81574052
6 · The paper itself

Abstract

objectiveTo investigate the anti-inflammatory effect of electroacupuncture in rats with bupivacaine-induced lumbar multifidus injury and its underlying regulatory mechanism on macrophage polarization.

methodsA total of seventy-two Sprague-Dawley male rats were randomly divided into control, model, and electroacupuncture groups. Forty-eight rats categorized in model groups were injected 0.5% bupivacaine (BPVC) into the lumbar multifidus at the L4-L5 segment. Rats in the electroacupuncture groups received the intervention for 1, 2, 3 and 5 d, respectively. The degree of macrophage infiltration and change of M1/M2 polarization were observed based on hematoxylin and eosin staining, immunohistochemistry and immunofluorescence to evaluate the anti-inflammatory effect of electroacupuncture. Meanwhile, exosomal miRNA-sequencing and bioinformatics analysis predicted the pathways and biological processes related to inflammatory response and macrophage polarization regulated by electroacupuncture intervention.

resultsBPVC injection induced the infiltration of local macrophages at the L4-L5 segment of lumbar multifidus. Comparison of mean IOD values with 2 d and 5 d post injury revealed the highest expression of CD68+ macrophages on day 3 post injury by immunohistochemistry. (

conclusionsElectroacupuncture can promote macrophage polarization to reduce inflammation following lumbar multifidus muscular injury.

Indexed as

Acupuncture PointsElectroacupunctureMacrophagesAnimalsHumansMaleRatsRats, Sprague-Dawleyelectro-acupunctureinflammationmacrophage polarizationmuscle repair

Identifiers

PMID40151120
PMCPMC11955755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.