Evidence map›Paper›PMID 40151119›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Electroacupuncture stimulation of auricular concha region improves loss of control over stress induced depression-like behavior by modulating 5-hydroxytryptamine 1A receptor.

L I Yongfeng, Chen Xinyi, Ren Wei, Qiao Haifa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

L I YongfengAcupuncture and Moxibustion College, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Chen XinyiAcupuncture and Moxibustion College, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Ren WeiFaculty of Education, Shaanxi Normal University, Xi'an 710062, China.
Qiao HaifaAcupuncture and Moxibustion College, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.

Funding

National Natural Science Foundation of China: Study on the Mechanisms of Learning and Memory Impairment induced by Chronic Pain and the Intervention Effects of Acupuncture 82004489Natural Science Foundation of Shaanxi Province: Acupuncture's Anxiolytic Effects in Uncontrollable Stress: Modulation of the Median Raphe Nucleus to Ventral Hippocampus Serotonergic Pathway 2022JQ-949
6 · The paper itself

Abstract

objectiveTo observe whether electroacupuncture stimulation of auricular concha region (EA-ACR) on behavior changes of depression by loss of control over stress model (LOC), and whether its effect is improved by regulating the expression levels of hydroxytryptamine (serotonin, 5-HT) 1A receptor (5-HT

methodsLOC was prepared using a Skinner box, and EA-ACR to observe behavioral changes, and Western Blot was used to detect the changes of 5-HT

resultsEA-ACR improve depressive-like behavior, up-regulated 5-HT

conclusionEA-ACR can improve depressive-like behaviors. Loss of control over stress leads to up-regulation of 5-HT

Indexed as

DepressionElectroacupunctureReceptor, Serotonin, 5-HT1AAcupuncture PointsAnimalsBehavior, AnimalHippocampusHumansMaleMiceRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2Aauricular concha regionelectroacupuncture stimulationhippocampusloss of control over stressreceptors, serotonin

Identifiers

PMID40151119
PMCPMC11955753

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.