Evidence map›Paper›PMID 40151117›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Effects of Huoxue Chubi decoction on protein kinase B-mammalian target of rapamycin autophagy pathway in scleroderma Balb/c model mice.

Chen Xi, Q U Tiange, Jia Hui, Duan Xingwu, L I Jianhong, Zhang Kaihui, Zhang Runtian, Wang Ruijie

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chen XiDepartment of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100107, China.
Q U TiangeDepartment of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100107, China.
Jia HuiDepartment of Surgery, Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing 101300, China.
Duan XingwuDepartment of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100107, China.
L I JianhongDepartment of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100107, China.
Zhang KaihuiDepartment of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100107, China.
Zhang RuntianDepartment of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100107, China.
Wang RuijieDepartment of Dermatology, the First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310060, China.

Funding

2023 Science and Technology Innovation Project Dongzhimen Hospital Beijing University of Chinese Medicine: Exploration the Mechanism of Radix Salviae Miltiorrhizae Components in Treating Scleroderma Fibrosis Based on PI3K-Akt-mTOR Signal Pathway about Autophagy DZMKJCX-2023-009Natural Science Foundation-funded Project: Exploration the Mechanism of Yiqi Huoxue Therapy in Treating Scleroderma Fibrosis based on Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (Akt)-Mammalian Target of Rapamycin (mTOR) Signal Pathway about Autophagy 81804106
6 · The paper itself

Abstract

objectiveTo explore the mechanisms by which Huoxue Chubi decoction (, HXCB) affects the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) autophagy pathway in scleroderma Balb/c model mice.

methodsA scleroderma model was established in male Balb/c mice, followed by daily administration of HXCB (4.6, 2.3 and 1.15 g·kg

resultsHXCB treatment significantly reduced epidermal and dermal thickness, dermal collagen levels, ROS levels and the mRNA and protein expression of factors in the Akt-mTOR signaling pathway compared to the scleroderma model group. Conversely, mice body weight and autophagy factors Beclin-1 and LC3 were significantly increased in mice receiving HXCB treatment. Moreover, finally, ROS expression positively correlated with skin thickness, collagen contents and the mRNA expression levels of Akt, while the protein and mRNA expression levels of Akt-mTOR pathway-related factors were inversely correlated with the protein and mRNA expression of Beclin-1 and LC3.

conclusionHXCB can regulate autophagy by invigorating

Indexed as

AutophagyDrugs, Chinese HerbalProto-Oncogene Proteins c-aktScleroderma, SystemicTOR Serine-Threonine KinasesAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred BALB CReactive Oxygen SpeciesSignal TransductionDrugs, Chinese HerbalProto-Oncogene Proteins c-aktReactive Oxygen SpeciesTOR Serine-Threonine KinasesautophagyHuoxue Chubi decoctionproto-oncogene proteins c-aktsclerodermaTOR serine-threonine kinases

Identifiers

PMID40151117
PMCPMC11955751

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.