Evidence map›Paper›PMID 40151103›Full record

ArticlePhysiological reports2025

A novel mouse model of diverse tumors derived from epithelial cells.

Bin Wang, Lingxiang Wang, Yang Liu, Yasmin Jahan-Mihan, Gordon He, Yuxi Wang, Jie Hu, Jiale Wang, Yan Bi, Baoan Ji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bin WangDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Lingxiang WangDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Yang LiuDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Yasmin Jahan-MihanDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Gordon HeDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Yuxi WangDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Jie HuDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Jiale WangDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
Yan BiDepartment of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.
Baoan JiDepartment of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0001-8971-1463

Funding

Project 4: ImmunovirotherapyP50CA210964 · NCI · MAYO CLINIC ROCHESTER · PI Zongming Eric Chen · 2018 to 2026
$20.5M
NCI NIH HHS P50 CA210964
6 · The paper itself

Abstract

A deeper understanding of pathophysiology, from the initiation of tumors of epithelial cells to the outcomes associated with it, is imperative to test potential interventions for these diseases. However, few models can accomplish this because of the complexity of origin cells and their transformation. We established an epithelial cell original tumor mouse model by conditional Kras

Indexed as

Disease Models, AnimalKeratin-19MiceNeoplasmsAnimalsEpithelial CellsFemaleIntegrasesMaleTamoxifenCre recombinaseIntegrasesKeratin-19TamoxifenCRISPRCytokeratin 19KrasG12Dp53tumors

Identifiers

PMID40151103
PMCPMC11950630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.