Evidence map›Paper›PMID 40151082›Full record

ReviewCurrent HIV research2026

Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.

David C Montefiori, Guido Ferrari, Dieter Mielke, LaTonya D Williams, Georgia D Tomaras

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current HIV research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David C MontefioriDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-0856-6319
Guido FerrariDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-7747-3349
Dieter MielkeDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-2182-0510
LaTonya D WilliamsDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-8064-8533
Georgia D TomarasDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-8076-1931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robust assay technologies and reference reagents are essential components in efforts to develop safe and effective antibody-mediated prevention strategies for HIV-1. Here, we describe current approaches used to conduct standardized assessments of neutralizing, binding, and Fc receptor-mediated effector functions of vaccine-elicited antibodies, with an emphasis on recent developments that enable early precursors and intermediates of broadly neutralizing antibodies (bnAbs) to be monitored. We also describe how these assay technologies were adapted to facilitate clinical evaluations of passively delivered bnAbs for HIV-1 prevention.

Indexed as

AIDS VaccinesAntibodies, NeutralizingHIV-1HIV AntibodiesHIV InfectionsHumansAIDS VaccinesAntibodies, NeutralizingHIV Antibodiesantibodiesantibody-mediated preventionbinding effectorHIV-1Neutralizingvaccine-elicited antibodies

Identifiers

PMID40151082

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.