ArticleAngewandte Chemie (International ed. in English)2025
3-Oxabicyclo[3.1.1]heptane as an Isostere of meta-Benzene.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Beyond para- and meta-Substitution: Synthesis and Biological Validation of Chalcogen-Rich Thiabicyclo[3.1.1]heptanes as Bioisosteres of Aryl Thioether Derivatives.Angewandte Chemie (International ed. in English) · 2026Article
- Hetero[3.1.1]propellanes.Nature chemistry · 2026Article
- Diversifying the triquinazine scaffold of a Janus kinase inhibitor.RSC medicinal chemistry · 2026Article
- Synthetic Methods for Four-Membered Carbocycles Bearing Emerging Fluorinated Motifs.Chemistry, an Asian journal · 2025Review
- Umpolung Activation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis.Angewandte Chemie (International ed. in English) · 2025Article
- Real-world experience of hetrombopag in immune thrombocytopenia treatment: a retrospective cohort study.European journal of medical research · 2025Article
- 3-Oxabicyclo[3.1.1]heptane as an Isostere of meta-Benzene.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
3-Oxabicyclo[3.1.1]heptanes were designed as saturated isosteres of meta-benzene. Crystallographic analysis revealed that these structures and meta-benzene have identical geometric properties. Replacement of the central benzene ring in the anticancer drug Sonidegib with 3-oxabicyclo[3.1.1]heptane provided a patent-free analogue with a nanomolar potency, reduced lipophilicity, and improved water solubility (>500%).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.