ArticleJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2025
Multimodal Prehabilitation in Head and Neck Cancer Patients Undergoing Surgery: A Feasibility Study.
Article in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- Longitudinal changes in cognition, sleep, and psychological distress following the MORE program in head and neck cancer patients undergoing chemoradiotherapy.Scientific reports · 2026Article
- The Impact of Malnutrition and Multimodal Prehabilitation on Quality of Life in Head and Neck Cancer Patients Following Resection and Microvascular Reconstruction: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Nutritional prehabilitation in head and neck cancer patients (PreHead) - A randomized controlled trial study protocol.PloS one · 2026Article
- The role of nutritional status and sarcopenia in treatment tolerance and toxicity in head and neck cancer: a narrative review.Frontiers in nutrition · 2026Review
- Functional dependence predicts adverse outcomes among geriatric otolaryngology patients better than more complex risk scales: a multivariate analysis of hospitalization risks on elderly group.Frontiers in medicine · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundHead and neck cancer (HNC) incidence is increasing, and surgery is frequently indicated as curative treatment. Unfortunately, complications and long-term functional impairment are common. Recent promising results of multimodal prehabilitation in colorectal cancer surgery show improved recovery and functional outcomes. The objective of this study is to assess the feasibility of multimodal prehabilitation, which is composed of high-intensity training, a protein-enriched diet, cessation of intoxications, mental support and speech support therapy, in HNC surgery.
methodsA feasibility study was conducted at a large teaching hospital, Northwest Clinics, Alkmaar, the Netherlands, between July 2022 and December 2023. The primary outcome was feasibility, defined as participation, dropout and adherence rate. The secondary outcome was functional capacity 6 weeks postoperatively.
resultsThe participation rate was 60% (30 of 50 patients), mainly limited due to the travel distance to the physiotherapist. A dropout rate of 7% was present, as two patients discontinued prehabilitation. Of the remaining 28 patients, 27 patients (96%) attended at least six sessions at the community physiotherapist practice. All functional tests increased by prehabilitation, with the 6-min walking test being significant (p ≤ 0.05). Six weeks postoperatively, all but steep ramp tests remained higher than baseline.
conclusionFeasibility of multimodal prehabilitation in HNC surgery patients in this study is limited by its participation rate of 60%. Addressing participation, a widespread network of oncologic physiotherapists or home-based multimodal prehabilitation by an app could possibly potentiate participation. More studies are needed to assess the optimal form of multimodal prehabilitation in this challenging population.
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