Observational studyJournal of cardiovascular electrophysiology2025
Durability of Ultra-Low Temperature Cryoablation Lesions in Atrial Fibrillation: Insights From Repeat Ablation Procedures.
Observational study in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Multicenter Investigation of the Adagio Cryoablation System in Patients With Atrial Fibrillation
iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study
Who cites it
1 citing paper in PubMed.
- Ablation lesion patterns in atrial fibrillation: A cardiac MRI comparison of different ablation strategies.Heart rhythm O2 · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUltra-low temperature cryoablation (ULTC) is a technique designed to rapidly cool cardiac tissue to extremely low temperatures, enabling the creation of ablation lesions for the treatment of atrial fibrillation (AF). Prior studies have demonstrated low rates of arrhythmia recurrence, but little is known about ablation lesion durability.
methodsPatients undergoing repeat ablation were selected from the CryoCure2 (NCT02839304) and iCLAS PMCF(NCT05416086) studies. Baseline patient and ULTC procedure characteristics were evaluated. During repeat ablation, ULTC ablation lesions were assessed for electrical block, including segment-based assessment of pulmonary vein (PV) ablation lesions. Arrhythmia outcomes after repeat ablation were evaluated.
resultsTwenty-five patients were included in the cohort: Age 68 ± 7 years, male 68%, persistent AF 68%, LAVI 42 ± 24 mL/m
conclusionReconnection of ablation targets during repeat ablation for arrhythmia recurrence following ULTC occurred at rates comparable to those observed with conventional thermal ablation modalities. The anterior side of the left PVs appears to be reconnected most often.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.