Evidence map›Paper›PMID 40150911›Full record

ArticleJournal of gynecologic oncology2025

Diagnostic accuracy and prognostic factors of uterine serous carcinoma in Japanese women: a multi-center study.

Shin Nishio, Kimio Ushijima, Mitsuya Ishikawa, Hideki Tokunaga, Koji Horie, Satoshi Yamaguchi, Shiro Suzuki, Hideaki Yahata, Hitoshi Tsuda, Toyomi Satoh and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shin NishioDepartment of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan. shinshin@med.kurume-u.ac.jp.ORCID 0000-0003-2526-630X
Kimio UshijimaDepartment of Obstetrics and Gynecology, JCHO Kurume General Hospital, Kurume, Japan.ORCID 0000-0002-6087-8873
Mitsuya IshikawaDepartment of Gynecology, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0001-8855-2966
Hideki TokunagaDepartment of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.ORCID 0000-0002-1622-3810
Koji HorieDepartment of Gynecology, Saitama Cancer Center, Ina, Japan.ORCID 0000-0003-2750-4308
Satoshi YamaguchiDepartment of Gynecologic Oncology, Hyogo Cancer Center, Akashi, Japan.ORCID 0000-0002-8260-6174
Shiro SuzukiDepartment of Gynecologic Oncology, Aichi Cancer Center, Nagoya, Japan.ORCID 0000-0003-0834-9285
Hideaki YahataDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0003-3142-8993
Hitoshi TsudaDepartment of Basic Pathology, National Defense Medical College, Tokorozawa, Japan.ORCID 0000-0003-3457-4224
Toyomi SatohDepartment of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0002-6929-5463
Japanese Clinical Oncology Group (JCOG) Gynecologic Cancer Study Group

Funding

NCC 23-A-17
6 · The paper itself

Abstract

objectiveThis multi-center retrospective study aimed to clarify the characteristics, diagnostic accuracy, treatment outcomes, and prognostic factors of uterine serous carcinoma (USC) in Japanese women.

methodsThe medical records of 193 patients who were treated between 2006 and 2008 at 24 participating institutions in the Japanese Clinical Oncology Group were examined, and pathological slides of 188 patients were re-checked through central pathology review (CPR), hematoxylin-eosin staining, and immunohistochemistry.

resultsUSC was confirmed in 144 of the 188 (76.6%) patients using CPR, and only 50% were correctly diagnosed preoperatively. Forty-three patients were diagnosed with non-serous carcinoma, whereas one patient had metastasis from another organ. The average age was 65.7 years, and 19% of patients had a history of other cancers. The incidence of stage III-IV disease was 52.8%, and lymph node metastasis was found in 28.5% of patients. Extrauterine spread and distant metastasis occurred in 39% and 14% of patients, respectively. The 2-year overall survival and progression-free survival (PFS) rates were 56% and 42%, respectively. The PFS of patients with stage I and II who underwent complete staging surgery was 92.3%, and that of those without lymph node dissection or omentectomy was 33.3%. Patients with USC had a significantly worse prognosis than 43 patients with non-serous carcinoma.

conclusionUSC in Japanese women has characteristics different from those of endometrioid carcinoma, worse prognosis, and is difficult to diagnose preoperatively. Complete surgical staging is necessary even for early-stage disease. Additionally, new adjuvant treatment strategies, including molecular targeted therapy, should be explored.

Indexed as

Cystadenocarcinoma, SerousUterine NeoplasmsAdultAgedAged, 80 and overEast Asian PeopleFemaleHumansJapanLymphatic MetastasisMiddle AgedNeoplasm StagingPrognosisProgression-Free SurvivalRetrospective StudiesDiagnostic AccuracyEndometrial CancerJapanese WomenPrognostic FactorsUterine Serous Carcinoma

Identifiers

PMID40150911
PMCPMC12636103

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