Evidence map›Paper›PMID 40150694›Full record

ArticleBioengineering (Basel, Switzerland)2025

In Vitro Functional and Structural Evaluation of Low-Complexity Artificial Human Epidermis for 3D Tissue Engineering.

Dorottya Kocsis, Dániel Sztankovics, Liza Józsa, Afrodité Németh, Tamás Garay, Márton Bese Naszlady, Miléna Lengyel, Miklós Vecsernyés, István Antal, Anna Sebestyén and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dorottya KocsisFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a., 1083 Budapest, Hungary.ORCID 0000-0001-7908-3248
Dániel SztankovicsDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26., 1085 Budapest, Hungary.ORCID 0009-0007-3168-1151
Liza JózsaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei krt. 98., 4032 Debrecen, Hungary.ORCID 0000-0001-5835-5304
Afrodité NémethFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a., 1083 Budapest, Hungary.
Tamás GarayFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a., 1083 Budapest, Hungary.
Márton Bese NaszladyFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a., 1083 Budapest, Hungary.ORCID 0000-0001-8114-1750
Miléna LengyelDepartment of Pharmaceutics, Semmelweis University, Hőgyes Endre u. 7, 1092 Budapest, Hungary.ORCID 0000-0001-8865-054X
Miklós VecsernyésDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei krt. 98., 4032 Debrecen, Hungary.ORCID 0000-0001-5719-975X
István AntalDepartment of Pharmaceutics, Semmelweis University, Hőgyes Endre u. 7, 1092 Budapest, Hungary.ORCID 0000-0002-5434-201X
Anna SebestyénDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26., 1085 Budapest, Hungary.ORCID 0000-0001-8814-4794
Franciska ErdőFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a., 1083 Budapest, Hungary.ORCID 0000-0001-6265-3777

Funding

National Research Development and Innovation Fund TKP2021-EGA-42Pázmány Péter Catholic University Research Scholarship Program (Egyetemi Kutatói Ösztöndíj Program) 2024-2.1.1-EKÖP
6 · The paper itself

Abstract

In recent times, with the need for a reduction, refinement, and replacement of in vivo animal testing, there has been an increasing demand for the use of relevant in vitro human cell systems in drug development. There is also a great demand for the replacement of skin tissue in various wounds and burns. Furthermore, human skin cell-based in vitro systems can be used to investigate the side effects (toxicity and irritation) and tissue penetration of topical preparations. In this study, exploratory experiments were performed to produce artificial epidermis using two hydrogel scaffolds, alginate and GelMA C. The amount of keratinocytes added to the matrix (10-50-100 × 10

Indexed as

alginateartificial epidermisbioinksGelMA CHaCaTmorphologypermeabilityskin barriertissue engineering

Identifiers

PMID40150694
PMCPMC11939566

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.