Evidence map›Paper›PMID 40150644›Full record

ArticleChildren (Basel, Switzerland)2025

Evaluating the Global Intensive Feeding Therapy (GIFT) for Children with CHARGE Syndrome: A Quasi-Experimental Study.

Antonella Cerchiari, Francesca Pizza, Giorgia Biondo, Carolina Giordani, Martina De Paolis, Gessica Della Bella, Massimiliano Raponi, Marco Tofani

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonella CerchiariManagement and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, 00050 Palidoro, Rome, Italy.ORCID 0009-0004-9324-2646
Francesca PizzaManagement and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, 00050 Palidoro, Rome, Italy.
Giorgia BiondoManagement and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, 00050 Palidoro, Rome, Italy.
Carolina GiordaniManagement and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, 00050 Palidoro, Rome, Italy.
Martina De PaolisSchool of Speech and Language Therapy, University of Tor Vergata, Campus of Tivoli, 00019 Tivoli, Italy.
Gessica Della BellaManagement and Diagnostic Innovations & Clinical Pathways Research Area, Neurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, 00050 Palidoro, Rome, Italy.ORCID 0000-0002-7160-0092
Massimiliano RaponiManagement and Diagnostic Innovations & Clinical Pathways Research Area, Medical Directorate, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Marco TofaniManagement and Diagnostic Innovations & Clinical Pathways Research Area, Professional Development, Continuous Education and Research Service, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0003-2071-4513

Funding

Italian Ministry of Health Current Research Funds
6 · The paper itself

Abstract

backgroundThis pilot investigation aimed to evaluate the efficacy of Global Intensive Feeding Therapy (GIFT) on feeding and swallowing abilities in children with CHARGE Syndrome (CS). GIFT is a novel rehabilitation program designed to leverage the principles of neuroplasticity, intensity, individualized treatment, and ecological validity. The program comprises 15 sessions conducted over one week, with sessions delivered three times per day.

methodsGIFT was preliminarily implemented in a cohort of seven children diagnosed with CS. To assess the risk of dysphagia, the Pediatric Screening-Priority Evaluation Dysphagia (PS-PED) was administered. The effectiveness of the intervention was evaluated using three instruments: the Karaduman Chewing Performance Scale (KCPS) for chewing performance, the American Speech-Language-Hearing Association National Outcome Measurement System (ASHA NOMS) for overall feeding abilities, and the Feeding Assessment Scale (FAS) to capture parents' perceptions. Data were collected at baseline (T0), immediately post-intervention (T1), and at a six-month follow-up (T2). The Wilcoxon signed-rank test was employed for statistical analysis, and effect sizes for specific outcomes were determined using Kendall's W.

resultsThe findings indicated that children with CS were at a high risk of dysphagia as measured by the PS-PED at baseline. Statistically significant improvements in chewing performance were observed at the six-month follow-up (

conclusionsThese preliminary results suggest that GIFT may be an effective rehabilitation program for addressing feeding and swallowing disorders in children with CS. Further studies with larger sample sizes and controlled designs are warranted to substantiate these findings and refine the intervention protocol.

Indexed as

CHARGE syndromechildrendysphagiafeedingGIFTrehabilitation

Identifiers

PMID40150644
PMCPMC11941461

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.