ArticleChildren (Basel, Switzerland)2025
Neonatal Mortality Due to Early-Onset Sepsis in Eastern Europe: A Review of Current Monitoring Protocols During Pregnancy and Maternal Demographics in Eastern Europe, with an Emphasis on Romania-Comparison with Data Extracted from a Secondary Center in Southern Romania.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Article
- Adolescent Pregnancy in Southeastern Romania: A Ten-Year Retrospective Cohort from a Regional Referral Center.Medicina (Kaunas, Lithuania) · 2025Article
- Maternal predictors of early-onset sepsis in neonates: a multicenter retrospective cohort study and risk prediction model.Journal of translational medicine · 2025Article
- Procalcitonin, Presepsin, Endocan, and Interleukin-6 in the Early Diagnosis of Neonatal Sepsis-A Prospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Effects of the COVID-19 pandemic on the emotional disorders of adolescents from rural high schools in Dobrogea, Romania.Frontiers in psychiatry · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal mortality, particularly due to early-onset sepsis (EOS), remains a pressing issue in Eastern Europe, with Romania experiencing one of the highest neonatal mortality rates in the European Union. EOS, caused by bacterial infections within the first 72 h of life, significantly contributes to neonatal deaths, particularly in rural and underserved areas where healthcare resources are limited. Disparities in prenatal care access, maternal demographics, and systemic healthcare gaps worsen this issue, highlighting the need for comprehensive interventions.
objectivesThis review aims to examine the prevalence of neonatal mortality due to EOS in Romania and the broader Eastern European context, focusing on current prenatal care monitoring protocols and maternal demographics, and comparing the available literature with new data. By evaluating disparities in healthcare access, costs, and outcomes, this study identifies systemic barriers to maternal and neonatal care.
methodsA systematic review of 100 articles was conducted using PRISMA guidelines. Key sources included PubMed, Google Scholar, and open-access journals, with 25 articles meeting the inclusion criteria. The analysis encompassed maternal age, parity, literacy levels, marital status, and their impact on neonatal outcomes, alongside the financial burden of prenatal care.
resultsThe findings underscore stark inequalities in healthcare delivery between rural and urban regions, where limited prenatal visits, out-of-pocket costs, and cultural barriers hinder prompt EOS prevention and management. Advanced maternal age, low literacy, and socioeconomic disparities were identified as critical risk factors.
conclusionsTo reduce neonatal mortality due to EOS, targeted efforts must address healthcare accessibility, improve prenatal care protocols, and integrate culturally sensitive practices. These interventions can bridge systemic gaps and promote equitable health outcomes for mothers and newborns across Eastern Europe.
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