ArticleChildren (Basel, Switzerland)2025
Open, Randomised, Controlled Study to Evaluate the Role of a Dietary Supplement Containing
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04899401 (A Randomized, Open, Controlled Study to Evaluate the Efficacy and Safety of PediaFlù®), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Open, Controlled Study to Evaluate the Efficacy and Safety of PediaFlù® (Dietary Supplement) Along With Standard of Care in Children With Acute Tonsillopharyngitis / Rhinopharyngitis Versus Standard of Care Only
Who cites it
2 citing papers in PubMed.
- Exploring the Antibacterial, Anti-Inflammatory, and Antioxidant Properties of the Natural Food Supplement "Antibiotics (Basel, Switzerland) · 2025Article
- Phytotherapeutic, Homeopathic Interventions and Bee Products for Pediatric Infections: A Scoping Review.Nutrients · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
objectivesA common reason for a pediatrician's visit is acute tonsillopharyngitis (ATR), which is usually caused by viruses. A dietary supplement comprising
methodsThis open randomized study (registered on ClinicalTrials.gov: NCT04899401) involved three Romanian sites specialized in pediatric care. The primary endpoints were changes in Tonsillitis Severity Score and the number of patients failing to respond (evaluating the use of ibuprofen or high-dose paracetamol as a rescue medication). One hundred and thirty children, distributed into two groups, were enrolled and treated for six days.
resultsThe results showed an overall better performance in terms of efficacy of dietary supplement + SoC, compared to SoC alone, with lower total Tonsillitis Severity Score ratings on day 6 (
conclusionsThe administration of the dietary supplement + SoC in pediatric patients with ATR was found to be safe and superior to the administration of SoC alone in terms of efficacy. The results confirmed that the tested dietary supplement is an optimum effective adjuvant in the treatment of respiratory tract infections and is suitable for the daily clinical practice of pediatricians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.