Evidence map›Paper›PMID 40150583›Full record

ArticleChildren (Basel, Switzerland)2025

Diagnostic Value of Umbilical Cord Blood Interleukin-6 Level in Premature Infants with Early-Onset Sepsis.

Jinfang Yuan, Yufeng Wu, Yahui Zhang, Lin Zeng, Jiansuo Zhou, Meihua Piao, Xiaomei Tong, Yuan Wei, Liyan Cui, Tongyan Han

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinfang YuanDepartment of Pediatric, Peking University Third Hospital, Beijing 100191, China.ORCID 0000-0003-1969-0307
Yufeng WuClinical Laboratory, Peking University Third Hospital, Beijing 100191, China.
Yahui ZhangDepartment of Pediatric, Peking University Third Hospital, Beijing 100191, China.
Lin ZengResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.ORCID 0000-0001-8707-5854
Jiansuo ZhouClinical Laboratory, Peking University Third Hospital, Beijing 100191, China.
Meihua PiaoDepartment of Pediatric, Peking University Third Hospital, Beijing 100191, China.
Xiaomei TongDepartment of Pediatric, Peking University Third Hospital, Beijing 100191, China.
Yuan WeiDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.ORCID 0000-0003-3387-7549
Liyan CuiClinical Laboratory, Peking University Third Hospital, Beijing 100191, China.
Tongyan HanDepartment of Pediatric, Peking University Third Hospital, Beijing 100191, China.

Funding

Clinical Cohort Construction Program of Peking University Third Hospital No.BYSYDL2022010.
6 · The paper itself

Abstract

objectiveEarly-onset sepsis (EOS) is a serious, grave, and frequently fatal condition in premature infants. This study aimed to assess the diagnostic value of interleukin-6 (IL-6) levels in umbilical cord blood for identifying EOS in preterm infants.

methodsThis prospective cohort study was conducted on preterm infants between May 2019 and April 2021. Based on the diagnostic criteria for EOS, the participants were divided into EOS and non-EOS groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of cord blood IL-6 levels for EOS.

resultsThe levels of IL-6 were significantly higher in the EOS group (

conclusionsThe detection of IL-6 in the umbilical cord blood offers convenience and exhibits significant diagnostic potential for EOS in preterm infants, thereby providing valuable support for clinical decision-making.

Indexed as

diagnostic valueearly-onset sepsisinterleukin-6premature infantumbilical cord blood

Identifiers

PMID40150583
PMCPMC11941668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.