ArticleHealthcare (Basel, Switzerland)2025
Impact of Placental Grading on Pregnancy Outcomes: A Retrospective Cohort Study.
Article in Healthcare (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Correlation Between Placental Calcification, Umbilical Artery Hemodynamic Parameters and Delivery Outcomes in Patients with Gestational Diabetes.International journal of women's health · 2026Article
- The placental maturation inflection point: an integrative biological framework for understanding early-onset versus late-onset preeclampsia.Frontiers in endocrinology · 2026Review
- The Association of Placental Grading with Perinatal Outcomes: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlacental grading remains underutilized in clinical practice despite its potential prognostic value. This study aimed to elucidate the relationship between premature placental calcification (PPC) and relevant perinatal outcomes in a large cohort.
methodsWe conducted a retrospective cohort study involving 3088 singleton pregnancies that underwent routine third-trimester ultrasound examinations (30
resultsIn total, 544 pregnancies (17.6%) had Grade 2 placentas, and 41 pregnancies (1.3%) had Grade 3 placentas. Compared to the control group, Grade 2 placentas were associated with increased odds of SGA (adjusted odds ratio [aOR] 1.80; 95% confidence intervals [CI]: 1.43-2.25) and FGR (aOR 1.81; 95% CI: 1.35-2.42). Grade 3 placentas showed even higher odds of SGA (aOR 3.09; 95% CI: 1.55-6.17) and FGR (aOR 3.26; 95% CI: 1.53-6.95). No significant associations were found between placental grading and preeclampsia or stillbirth. Additionally, PPC was linked to lower birthweight percentiles and earlier gestational age at birth.
conclusionsPremature placental calcification (before 36
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