Evidence map›Paper›PMID 40150440›Full record

ReviewHealthcare (Basel, Switzerland)2025

Should Artificial Intelligence-Based Patient Preference Predictors Be Used for Incapacitated Patients? A Scoping Review of Reasons to Facilitate Medico-Legal Considerations.

Pietro Refolo, Dario Sacchini, Costanza Raimondi, Simone S Masilla, Barbara Corsano, Giulia Mercuri, Antonio Oliva, Antonio G Spagnolo

Abstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pietro RefoloResearch Centre for Clinical Bioethics & Medical Humanities, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.ORCID 0000-0003-1055-160X
Dario SacchiniResearch Centre for Clinical Bioethics & Medical Humanities, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.ORCID 0000-0002-1581-3018
Costanza RaimondiResearch Centre for Clinical Bioethics & Medical Humanities, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Simone S MasillaResearch Centre for Clinical Bioethics & Medical Humanities, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Barbara CorsanoFondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168 Rome, Italy.
Giulia MercuriDepartment of Health Care Surveillance and Bioethics, Section of Legal Medicine, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Antonio OlivaFondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168 Rome, Italy.ORCID 0000-0001-7112-9096
Antonio G SpagnoloResearch Centre for Clinical Bioethics & Medical Humanities, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.ORCID 0000-0002-5762-2164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch indicates that surrogate decision-makers often struggle to accurately interpret and reflect the preferences of incapacitated patients they represent. This discrepancy raises important concerns about the reliability of such practice. Artificial intelligence (AI)-based Patient Preference Predictors (PPPs) are emerging tools proposed to guide healthcare decisions for patients who lack decision-making capacity.

objectivesThis scoping review aims to provide a thorough analysis of the arguments, both for and against their use, presented in the academic literature.

methodsA search was conducted in PubMed, Web of Science, and Scopus to identify relevant publications. After screening titles and abstracts based on predefined inclusion and exclusion criteria, 16 publications were selected for full-text analysis.

resultsThe arguments in favor are fewer in number compared to those against. Proponents of AI-PPPs highlight their potential to improve the accuracy of predictions regarding patients' preferences, reduce the emotional burden on surrogates and family members, and optimize healthcare resource allocation. Conversely, critics point to risks including reinforcing existing biases in medical data, undermining patient autonomy, raising critical concerns about privacy, data security, and explainability, and contributing to the depersonalization of decision-making processes.

conclusionsFurther empirical studies are needed to assess the acceptability and feasibility of these tools among key stakeholders, such as patients, surrogates, and clinicians. Moreover, robust interdisciplinary research is needed to explore the legal and medico-legal implications associated with their implementation, ensuring that these tools align with ethical principles and support patient-centered and equitable healthcare practices.

Indexed as

artificial intelligence (AI)incapacitated patientspatient preference predictors (PPPs)surrogate decision-making

Identifiers

PMID40150440
PMCPMC11942106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.