Evidence map›Paper›PMID 40149984›Full record

ArticleBiomolecules2025

Enhancing Antimicrobial Peptides from Frog Skin: A Rational Approach.

Silvana Aguilar, Daniel Moreira, Ana Laura Pereira Lourenço, Natalia Wilke, Matías A Crosio, Andreanne Vasconcelos, Eder Alves Barbosa, Elizabete C I Bispo, Felipe Saldanha-Araujo, Marcelo H S Ramada and 4 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Silvana AguilarIPEEC-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn U9120ACD, Argentina.
Daniel MoreiraResearch Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0003-1961-7281
Ana Laura Pereira LourençoPrograma de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Taguatinga 71966-700, DF, Brazil.ORCID 0000-0002-7252-3105
Natalia WilkeFacultad de Ciencias Químicas, Departamento de Química Biológica Ranwel Caputto, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.ORCID 0000-0002-2342-0193
Matías A CrosioFacultad de Ciencias Químicas, Departamento de Química Biológica Ranwel Caputto, Universidad Nacional de Córdoba, Córdoba X5000HUA, Argentina.ORCID 0000-0002-3975-602X
Andreanne VasconcelosResearch Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-9651-1598
Eder Alves BarbosaResearch Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-7613-4414
Elizabete C I BispoLaboratory of Hematology and Stem Cells, Faculty of Health Sciences, University of Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0009-0002-7593-1849
Felipe Saldanha-AraujoLaboratory of Hematology and Stem Cells, Faculty of Health Sciences, University of Brasília, UnB, Brasília 70910-900, DF, Brazil.
Marcelo H S RamadaPrograma de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Taguatinga 71966-700, DF, Brazil.
Franco M EscobarDepartamento de Microbiología e Inmunología, Universidad Nacional de Río Cuarto, Ruta 36, Km 601, Río Cuarto 5800, Argentina.
Cristina V TorresDepartamento de Microbiología e Inmunología, Universidad Nacional de Río Cuarto, Ruta 36, Km 601, Río Cuarto 5800, Argentina.
José R S A LeiteResearch Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-1096-3236
Mariela M MaraniIPEEC-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn U9120ACD, Argentina.ORCID 0000-0002-7389-3095

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2019 N°1045, PICT 2020 N° 3296CONICET PIP 11220200102800CO
6 · The paper itself

Abstract

Antimicrobial resistance is a global health threat, which has been worsened by the slow development of new antibiotics. The rational design of natural-derived antimicrobial peptides (AMPs) offers a promising alternative for enhancing the efficacy of AMPs and accelerating drug discovery. This paper describes the rational design of improved peptide derivatives starting from hylin-Pul3, a peptide previously isolated from the frog

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesSkinAnimalsAnuraGram-Negative BacteriaHemolysisHumansHydrophobic and Hydrophilic InteractionsMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptidesamphipathiccell selectivityhylinsin silico designpeptide–membrane interactions

Identifiers

PMID40149984
PMCPMC11939955

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.