Evidence map›Paper›PMID 40149968›Full record

ArticleBiomolecules2025

Vitamin D Decreases Susceptibility of CD4

John D Loaiza, Jose Fernando Gómez, Daniel Muñoz-Escudero, Sandra M Gonzalez, Timothy Kyle Eubank, Maria T Rugeles, Ana Lucía Rodríguez-Perea, Wbeimar Aguilar-Jimenez

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John D LoaizaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.ORCID 0000-0003-2373-9791
Jose Fernando GómezGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.ORCID 0000-0001-7737-6127
Daniel Muñoz-EscuderoGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.ORCID 0000-0002-3884-7093
Sandra M GonzalezSexually Transmitted and Blood-Borne Infections Division at JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB R3E 3L5, Canada.
Timothy Kyle EubankGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.
Maria T RugelesGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.
Ana Lucía Rodríguez-PereaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.
Wbeimar Aguilar-JimenezGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín 050010, ANT, Colombia.ORCID 0000-0002-0790-055X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activated immune cells are highly susceptible to human immunodeficiency virus (HIV) infection. Vitamin D (VitD) induces antimicrobial responses and reduces cellular activation. We investigated VitD effects on HIV-1 replication, glucose uptake, and gene regulation using computational and in vitro approaches. CD4

Indexed as

CD4-Positive T-LymphocytesGlucoseHIV InfectionsProto-Oncogene Proteins c-aktVitamin DComputational BiologyHIV-1HumansMalePhosphorylationReceptors, CCR5Receptors, CXCR4Virus ReplicationGlucoseProto-Oncogene Proteins c-aktReceptors, CCR5Receptors, CXCR4Vitamin DAKT signalinganti-HIV mechanismsBoolean modelingglucose uptakeHIVHIV-1 replicationprotein kinase Bvitamin D

Identifiers

PMID40149968
PMCPMC11940553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.