Evidence map›Paper›PMID 40149933›Full record

ArticleBiomolecules2025

Computational Design and In Vitro and In Vivo Characterization of an ApoE-Based Synthetic High-Density Lipoprotein for Sepsis Therapy.

Ling Guo, Yaxia Yuan, Fang Zheng, Changguo Zhan, Xiangan Li

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ling GuoSaha Cardiovascular Research Center, Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Yaxia YuanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0001-7094-4419
Fang ZhengDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Changguo ZhanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Xiangan LiSaha Cardiovascular Research Center, Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-6899-7332

Funding

Synthetic HDL_a potential sepsis therapyR01GM113832 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN, SCHWENDEMAN, ANNA · 2015 to 2019
$3.0M
Relative adrenal insufficiency as a risk factor and an endotype for sepsisR35GM141478 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN · 2021 to 2025
$1.9M
BLRD VA I01 BX004639BLRD VA I01 BX006408NIGMS NIH HHS R01 GM113832NIGMS NIH HHS R35 GM141478NIH HHS 1P20GM130456-02A1NIH HHS 1R35GM141478-05A1US Department of Veterans Affairs 1I01BX004639 and I01BX006408
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Apolipoproteins ELipoproteins, HDLSepsisAnimalsDisease Models, AnimalHEK293 CellsHumansMaleMiceMice, Inbred C57BLNanoparticlesPseudomonas aeruginosaApolipoproteins ELipoproteins, HDLcomputational designHDLnanoparticlesepsistherapy

Identifiers

PMID40149933
PMCPMC11940477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.