Evidence map›Paper›PMID 40149888›Full record

ArticleBiomolecules2025

Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres.

Martina Piškor, Astrid Milić, Sanja Koštrun, Maja Majerić Elenkov, Petra Grbčić, Sandra Kraljević Pavelić, Krešimir Pavelić, Silvana Raić-Malić

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review of promising benzimidazole-based anticancer agents (2023-2026).Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martina PiškorDepartment of Organic Chemistry, University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 19, 10000 Zagreb, Croatia.ORCID 0000-0002-0433-066X
Astrid MilićSelvita d.o.o., 10000 Zagreb, Croatia.
Sanja KoštrunSelvita d.o.o., 10000 Zagreb, Croatia.
Maja Majerić ElenkovDivision of Organic Chemistry and Biochemistry, Ruder Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia.
Petra GrbčićJuraj Dobrila University of Pula, Faculty of Medicine, 52100 Pula, Croatia.
Sandra Kraljević PavelićFaculty of Health Studies, University of Rijeka, Viktora Cara Emina 5, 51000 Rijeka, Croatia.ORCID 0000-0003-0491-673X
Krešimir PavelićJuraj Dobrila University of Pula, Faculty of Medicine, 52100 Pula, Croatia.ORCID 0000-0001-7706-6858
Silvana Raić-MalićDepartment of Organic Chemistry, University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 19, 10000 Zagreb, Croatia.ORCID 0000-0001-5021-8970

Funding

Croatian Science Foundation IP-2022-10-9420
6 · The paper itself

Abstract

The aim of this study was to synthesize new racemic and optically pure aryl-substituted purine bioisosteres using ultrasound-assisted Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Regioselective synthesis of α-azido alcohols was applied to afford heterocycles with a 2-hydroxyeth-1-yl linker. Catalytic asymmetric synthesis using halohydrin dehalogenase in the ring-opening of epoxides gave enantioenriched azido alcohols, which subsequently afforded

Indexed as

Antineoplastic AgentsPurinesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansPyrimidinesStereoisomerismAntineoplastic AgentsPurinesPyrimidinesADME profilingantiproliferative activitypurinepurine bioisosteres

Identifiers

PMID40149888
PMCPMC11940194

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.