Evidence map›Paper›PMID 40149887›Full record

ArticleBiomolecules2025

Cetuximab and Paclitaxel Drug Response in Head and Neck Tumor Stem Cells.

Vilson Serafim Júnior, Glaucia Maria de Mendonça Fernandes, Bianca Barbério Bogdan Tedeschi, Caroline Izak Cuzziol, Márcia Maria Urbanin Castanhole-Nunes, Letícia Antunes Muniz Ferreira, Gabriela Helena Rodrigues, Juliana Garcia de Oliveira-Cucolo, Érika Cristina Pavarino, Eny Maria Goloni-Bertollo

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vilson Serafim JúniorGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-3349-0531
Glaucia Maria de Mendonça FernandesGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-8113-3598
Bianca Barbério Bogdan TedeschiGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-1881-1667
Caroline Izak CuzziolGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0003-3552-6259
Márcia Maria Urbanin Castanhole-NunesGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-5506-8155
Letícia Antunes Muniz FerreiraGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0003-4840-8753
Gabriela Helena RodriguesGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-6714-6931
Juliana Garcia de Oliveira-CucoloGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-2125-9930
Érika Cristina PavarinoGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0003-0959-0695
Eny Maria Goloni-BertolloGenetics and Molecular Biology Research Unit [UPGEM], Faculty of Medicine of São José do Rio Preto [FAMERP], Avenida Brigadeiro Faria Lima, number 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0002-2622-4673

Funding

Coordination for the Improvement of Higher Education Personnel - CAPES 001National Council for Scientific and Technological Development - CNPq 310987/2018-0São Paulo Research Foundation - FAPESP 2018/26166-6
6 · The paper itself

Abstract

Head and neck cancer (HNC) is one of the most common types of cancer in the world, characterized by resistance to conventional therapies and an unfavorable prognosis due to the presence of tumor stem cells (TSCs). TSCs are cell subpopulations with high potential for invasion, migration, and metastasis, being responsible for the initiation and dissemination of cancer. This study aimed to evaluate the efficacy of treatments with cetuximab and paclitaxel, alone and in combination, in TSCs from oral cavity (SCC-28) and hypopharynx (FADU) cancer cell lines. In addition, the influence of the gene and protein expression of EGFR,

Indexed as

CetuximabHead and Neck NeoplasmsNeoplastic Stem CellsPaclitaxelCell Line, TumorCell SurvivalDrug Resistance, NeoplasmErbB ReceptorsGene Expression Regulation, NeoplasticHumansHypoxia-Inducible Factor 1, alpha SubunitCetuximabErbB ReceptorsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitPaclitaxelcancer treatmentcell signaling pathwayschemotherapygene expressionhead and neck cancertumor stem cells

Identifiers

PMID40149887
PMCPMC11940455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.