ArticleBrain sciences2025
Identification of Brain Activation Areas in Response to Active Tactile Stimulation by Gripping a Stress Ball.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- EEG Evidence for Dynamic Cross-Modal Adaptation Under Progressive Visual-Tactile Impairment.Brain sciences · 2026Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND/
objectivesResearch on pleasant tactile perception has primarily focused on C-tactile fibers found in hairy skin, with the forearm and face as common study sites. Recent findings of these fibers in hairless skin, such as the palms, have sparked interest in tactile stimulation on the hands. While studies have examined comfort and brain activity in passive touch, active touch remains underexplored. This study aimed to investigate differences in pleasant sensation and brain activity during active touch with stress balls of varying hardness.
methodsForty healthy women participated. Using functional magnetic resonance imaging (fMRI), brain activity was measured as participants alternated between gripping stress balls of soft, medium, and hard hardness and resting without a ball. Participants rated hardness and comfort on a 9-point scale.
resultsSoft stress balls were perceived as soft and comfortable, activating the thalamus and left insular cortex while reducing activity in the right insular cortex. Medium stress balls elicited similar perceptions and thalamic activation but with reduced right insular cortex activity. Hard stress balls caused discomfort, activating the insular cortex, thalamus, and amygdala while reducing anterior cingulate cortex activity.
conclusionsSoft stress balls may reduce aversive stimuli through perceived comfort, while hard stress balls may induce discomfort and are unlikely to alleviate stress.
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Registered trials
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