Evidence map›Paper›PMID 40149773›Full record

ArticleBrain sciences2025

Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury.

Juan Sebastián Jara, Marwa A Soliman, Amanda Bernstein, Paola di Grazia, Adam R Ferguson, Justin M Brown, Abel Torres-Espín, Edmund R Hollis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan Sebastián JaraBurke Neurological Institute, White Plains, NY 10605, USA.
Marwa A SolimanBurke Neurological Institute, White Plains, NY 10605, USA.ORCID 0000-0001-7118-4546
Amanda BernsteinBurke Neurological Institute, White Plains, NY 10605, USA.ORCID 0000-0002-6619-4878
Paola di GraziaBurke Neurological Institute, White Plains, NY 10605, USA.
Adam R FergusonBrain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
Justin M BrownMassachusetts General Paralysis Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Abel Torres-EspínBrain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
Edmund R HollisBurke Neurological Institute, White Plains, NY 10605, USA.ORCID 0000-0002-4535-4668

Funding

Tools for Common Data Element Adoption in the Pan-Neurotrauma Data Commons (PANORAUMA)U24NS122732 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADAM R FERGUSON, Jeffrey S. Grethe · 2021 to 2026
$5.0M
Maladaptive Plasticity in Spinal Cord Injury: Cellular MechanismsR01NS122888 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERGUSON, ADAM R · 2021 to 2025
$3.0M
Modulation of cortical networks, a new approach to spinal cord injury rehabilitationDP2NS106663 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI HOLLIS, EDMUND R · 2017 to 2020
$2.8M
Advanced, multi-function, inverted confocal microscope for BNI Structural and Functional Imaging CoreS10OD028547 · OD · WINIFRED MASTERSON BURKE MED RES INST · PI HOLLIS, EDMUND R · 2020 to 2020
$530k
BLRD VA I01 BX005871BLRD VA I50 BX005878National Institutes of Health, Office of the Director 1 S10 OD028547-01New York State Department of Health C34463GGNIH HHS 1DP2NS106663-17A1NIH HHS S10 OD028547NINDS NIH HHS DP2 NS106663NINDS NIH HHS R01 NS122888NINDS NIH HHS U24 NS122732Paralyzed Veterans of America Research Foundation PVA22_R_00037RRD VA I01 RX002245RRD VA I01 RX002787
6 · The paper itself

Abstract

BACKGROUND/

objectivesNerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic spinal cord injury may benefit from this intervention, variability in outcomes can limit the functional impact. A bedside to bench approach was taken to address the variable response of tetraplegic individuals to nerve transfer surgery.

methodsWe used a hierarchical multiple factor analysis to evaluate the effects of conditioning electrical stimulation (CES) on outcomes in a mouse model of nerve transfer to treat chronic cervical spinal cord injury.

resultsWe found that CES of donor nerves one week prior to nerve transfer surgery enhanced anatomical and functional measures of innervation of targeted muscles. Furthermore, CES increased the rate of recovery of naturalistic behavior.

conclusionsWhile the model has some limitations due to the small size of the rodent, our results support the use of CES as an effective approach to improve outcomes in clinical nerve repair settings.

Indexed as

chronic spinal cord injurymouse modelmovement recoverynerve transfer surgeryrecoveryregenerationreinnervationtetraplegiatranslation

Identifiers

PMID40149773
PMCPMC11940277

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.