Evidence map›Paper›PMID 40149659›Full record

ReviewBiomedicines2025

HFE-Related Hemochromatosis May Be a Primary Kupffer Cell Disease.

Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elias KouroumalisDepartment of Gastroenterology, PAGNI University Hospital, University of Crete Medical School, 71500 Heraklion, Greece.ORCID 0000-0002-6875-906X
Ioannis TsomidisLaboratory of Gastroenterology and Hepatology, University of Crete Medical School, 71500 Heraklion, Greece.ORCID 0000-0002-8595-2750
Argyro Voumvouraki1st Department of Internal Medicine, AHEPA University Hospital, 54621 Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron overload can lead to increased deposition of iron and cause organ damage in the liver, the pancreas, the heart and the synovium. Iron overload disorders are due to either genetic or acquired abnormalities such as excess transfusions or chronic liver diseases. The most common genetic disease of iron deposition is classic hemochromatosis (HH) type 1, which is caused by mutations of

Indexed as

bone morphogenetic proteinserythroferroneferroportinhepcidinhereditary hemochromatosisironKupffer cellsliver sinusoidal endothelial cells

Identifiers

PMID40149659
PMCPMC11940282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.