Evidence map›Paper›PMID 40149645›Full record

ArticleBiomedicines2025

Genetic Polymorphisms on TNFA, TNFRSF1A, and TNFRSF1B Genes Predict the Effectiveness of Anti-TNF-α Treatment in Inflammatory Bowel Disease Patients.

Michelangelo Rottura, Igor Pirrotta, Domenico Antonio Giorgi, Natasha Irrera, Vincenzo Arcoraci, Federica Mannino, Rosario Campisi, Chiara Bivacqua, Laura Patanè, Giuseppe Costantino and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Journal of clinical medicine · 2026
    Article
  4. Article
  5. Pharmacogenomics of TNF inhibitors.Frontiers in immunology · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michelangelo RotturaDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0001-5407-6535
Igor PirrottaDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Domenico Antonio GiorgiDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Natasha IrreraDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0002-1134-7080
Vincenzo ArcoraciDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0003-0061-0477
Federica ManninoDepartment of Medicine and Surgery, University of Enna "Kore", Contrada Santa Panasia, 94100 Enna, Italy.
Rosario CampisiDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Chiara BivacquaDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Laura PatanèDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0009-0006-9044-313X
Giuseppe CostantinoIBD-Unit, University Hospital Gaetano Martino, Via C. Valeria, 98125 Messina, Italy.
Socrate PallioDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Walter FriesDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Anna ViolaDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Giovanni PallioDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0002-4187-2265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adalimumabCrohn’s diseaseinflammatory bowel diseasesinfliximabpolymorphismsprecision medicineulcerative colitis

Identifiers

PMID40149645
PMCPMC11939863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.