Evidence map›Paper›PMID 40149502›Full record

ArticleGenes2025

SARS-CoV-2 Genetic Variants Identified in Selected Regions of Ethiopia Through Whole Genome Sequencing: Insights from the Fifth Wave of COVID-19.

Getnet Hailu, Mengistu Legesse, Andargachew Mulu, Girmay Medhin, Mesfin Mengesha Tsegaye, Dawit Hailu Alemayehu, Abaysew Ayele, Atsbeha Gebreegziabxier, Adamu Tayachew, Adimkewu Aguine and 7 more

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PubMed Full text at PMC Publisher
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Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Getnet HailuAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Mengistu LegesseAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Andargachew MuluArmaur Hansson Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.ORCID 0000-0003-2862-0175
Girmay MedhinAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Mesfin Mengesha TsegayeArmaur Hansson Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.ORCID 0000-0002-7756-9110
Dawit Hailu AlemayehuArmaur Hansson Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.ORCID 0000-0002-4118-8260
Abaysew AyeleArmaur Hansson Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.
Atsbeha GebreegziabxierEthiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia.ORCID 0000-0003-1987-6996
Adamu TayachewAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.ORCID 0000-0001-6338-9824
Adimkewu AguineEthiopian Public Health Institute, Addis Ababa P.O. Box 1242, Ethiopia.
Haileyesus DejeneCollege of Veterinary and Animal Science, University of Gondar, Gondar P.O. Box 196, Ethiopia.
Sofonias K TessemaAfrica Centres for Disease Control and Prevention (Africa CDC), Addis Ababa P.O. Box 3243, Ethiopia.
Harris OnyweraAfrica Centres for Disease Control and Prevention (Africa CDC), Addis Ababa P.O. Box 3243, Ethiopia.ORCID 0000-0002-7298-4921
Assohoun Egomli StanislasGenomics and Metagenomics Platform, Pasteur Institute, Abidjan P.O. Box 75015, Côte d'Ivoire.
Ebba AbateAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Alessandro MarcelloLaboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy.ORCID 0000-0002-8903-8202
Molalegne BitewBio and Emerging Technology Institute, Addis Ababa P.O. Box 5954, Ethiopia.ORCID 0000-0002-9016-2630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic highlighted SARS-CoV-2 variants with increased transmissibility and immune evasion. In Ethiopia, where cases surged, the understanding of the virus's dynamics was limited. This study analyzed SARS-CoV-2 variants during the fifth wave, crucial for guiding vaccines, therapeutics, diagnostics, and understanding disease severity.

methodFrom June to August 2022, 150 SARS-CoV-2-positive samples were randomly selected from the Ethiopian Public Health Institute repository. Sixty-three high-quality genome sequences were analyzed.

resultsOf the 63 sequences, 70% were from males and 30% from females, with a median age of 34. Omicron dominated (97%, 61/63), primarily clade 22A (64%, 40/63), followed by 22B (18%, 11/63) and 21K (14%, 9/63). Delta accounted for 3.2% (2/63). Omicron was identified in all (25) vaccinated study participants. Ethiopian sequences showed limited evolutionary divergence and lower genetic diversity compared to global sequences.

conclusionOmicron was the predominant variant during Ethiopia's fifth wave, indicating recent community transmission. Despite minor genetic diversity differences, ongoing surveillance remains critical for tracking variants and informing public health interventions.

Indexed as

COVID-19SARS-CoV-2AdolescentAdultEthiopiaFemaleGenetic VariationGenome, ViralHumansMaleMiddle AgedPhylogenyWhole Genome SequencingYoung AdultEthiopiafifth wavegenetic divergenceSARS-CoV-2whole genome sequencing

Identifiers

PMID40149502
PMCPMC11942139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.