Evidence map›Paper›PMID 40149412›Full record

ArticleGenes2025

An Extensive Gap Junction Neural Network Modulates

Savannah E Sojka, Meredith J Ezak, Emily A Polk, Andrew P Bischer, Katherine E Neyland, Andrew P Wojtovich, Denise M Ferkey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Phosphodiesterases RegulatemicroPublication biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Savannah E SojkaFerkey Laboratory, Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Meredith J EzakFerkey Laboratory, Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Emily A PolkFerkey Laboratory, Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Andrew P BischerWojtovich Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Katherine E NeylandWojtovich Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Andrew P WojtovichWojtovich Laboratory, Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Denise M FerkeyFerkey Laboratory, Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

Funding

Mitochondrial ROS Microdomains and Neuronal IschemiaR01NS092558 · NINDS · UNIVERSITY OF ROCHESTER · PI WOJTOVICH, ANDREW PHILLIP · 2015 to 2025
$3.7M
Mitochondrial Energy Sensing and Neuronal IschemiaR01NS115906 · NINDS · UNIVERSITY OF ROCHESTER · PI Andrew P Wojtovich · 2020 to 2026
$3.0M
Gap Junction-Mediated Regulation of Nociceptive Sensory SignalingR01DC015758 · NIDCD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FERKEY, DENISE MARIE · 2017 to 2021
$1.7M
NIDCD NIH HHS R01 DC015758NIH HHS R01DC015758NINDS NIH HHS R01 NS092558NINDS NIH HHS R01 NS115906
6 · The paper itself

Abstract

BACKGROUND/

objectives

methodsHere, we used genetic mutants and a combination of cell-selective rescue and knockdown experiments to identify gap junction proteins (innexins) involved in modulating ASH-mediated nociceptive behavioral responses.

resultsWe have characterized six additional

conclusionsThis work expands our understanding of the extent to which ASH sensitivity can be tuned in a non-cell-autonomous manner.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsGap JunctionsNerve NetAnimalsAvoidance LearningBehavior, AnimalConnexinsNociceptionSensory Receptor CellsCaenorhabditis elegans ProteinsConnexinsavoidancebehaviorC. eleganscGMPchemosensationgap junctioninnexinnociception

Identifiers

PMID40149412
PMCPMC11941935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.