Evidence map›Paper›PMID 40149404›Full record

ReviewGenes2025

The Heterogeneity of 13q Deletions in Chronic Lymphocytic Leukemia: Diagnostic Challenges and Clinical Implications.

Changqing Xia, Guang Liu, Jinglan Liu, Arash Ronaghy, Saber Tadros, Wei Wang, Hong Fang, Shanxiang Zhang, Joseph D Khoury, Zhenya Tang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. ComplexInternational journal of molecular sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changqing XiaDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Guang LiuSonora Quest Laboratories, Department of Pathology, University of Arizona College of Medicine, Phoenix, AZ 85034, USA.ORCID 0000-0003-1881-2122
Jinglan LiuDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Arash RonaghyDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Saber TadrosDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Wei WangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77015, USA.
Hong FangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77015, USA.ORCID 0000-0003-1780-5959
Shanxiang ZhangDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Joseph D KhouryDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-2621-3584
Zhenya TangDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-8079-9945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia, particularly in Western countries. CLL can present indolently or aggressively, influenced by various factors, including chromosomal alterations. Fluorescent in situ hybridization (FISH), targeting specific genes/loci frequently affected in CLL patients, has established a standard for stratifying five CLL prognostic groups: del(11q)/

Indexed as

Chromosome DeletionChromosomes, Human, Pair 13Leukemia, Lymphocytic, Chronic, B-CellChromosome DisordersGenetic HeterogeneityHumansIn Situ Hybridization, FluorescencePrognosischromosomal microarray (CMA)chronic lymphocytic leukemia (CLL)del(13q)fluorescence in situ hybridization (FISH)karyotypingminimally deleted region (MDR)optical genome mapping (OGM)

Identifiers

PMID40149404
PMCPMC11941828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.