Evidence map›Paper›PMID 40149395›Full record

ArticleGenes2025

MicroRNA Expression Profile Analysis in Blood During Giant Panda (

Shanshan Ling, Die Deng, Fuxing Yang, Pingfeng Wang, Ming He, Qian Wang, Linhua Deng, Xun Wang, Ling Zhao, Gang Ye and 1 more

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Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Shanshan LingChina Conservation and Research Centre for the Giant Panda, Dujiangyan, Chengdu 611800, China.
Die DengCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Fuxing YangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Pingfeng WangChina Conservation and Research Centre for the Giant Panda, Dujiangyan, Chengdu 611800, China.
Ming HeChina Conservation and Research Centre for the Giant Panda, Dujiangyan, Chengdu 611800, China.
Qian WangChina Conservation and Research Centre for the Giant Panda, Dujiangyan, Chengdu 611800, China.
Linhua DengChina Conservation and Research Centre for the Giant Panda, Dujiangyan, Chengdu 611800, China.
Xun WangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Ling ZhaoCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Gang YeCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Xiaoyu HuangChina Conservation and Research Centre for the Giant Panda, Dujiangyan, Chengdu 611800, China.

Funding

China Conservation and Research Centre for the Giant Panda CCRCGP222324
6 · The paper itself

Abstract

BACKGROUND/

objectivesBlood is an essential component of the immune system. As post-transcriptional regulators, miRNAs, abundant in blood, are necessary aspects in blood's immune and physiological functions. However, there is limited knowledge about the expression and function of miRNAs in the blood of giant pandas.

methodsWe comparatively analyzed miRNA expression profiles in the blood of giant pandas of different ages using small-RNA sequencing technology.

resultsWe identified 393 known miRNAs, 219 conserved miRNAs, and 71 novel miRNAs in the blood of giant pandas, and functional enrichment analysis showed that the genes regulated by DE (differentially expressed) miRNAs were mainly enriched in the regulation of enzyme-linked receptor protein signaling pathways and the signaling pathways of MAPK, Hippo, and FoXO.

conclusionsOur study clarified giant pandas' blood miRNA expression profiles at different developmental stages, which will help elucidate the blood immunity and regulation of blood cell physiological functions in giant pandas.

Indexed as

MicroRNAsTranscriptomeUrsidaeAnimalsGene Expression ProfilingGene Expression Regulation, DevelopmentalSignal TransductionMicroRNAsblooddevelopmentgiant pandaimmunitymiRNA

Identifiers

PMID40149395
PMCPMC11942061

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