Evidence map›Paper›PMID 40149344›Full record

ArticleCancers2025

Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure.

Emeshaw Damtew Zebene, Biagio Pucci, Rita Lombardi, Hagos Tesfay Medhin, Edom Seife, Elena Di Gennaro, Alfredo Budillon, Gurja Belay Woldemichael

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emeshaw Damtew ZebeneNuclear Medicine Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0009-0007-3968-6950
Biagio PucciExperimental Pharmacology Unit, Laboratory of Naples and Mercogliano (AV), Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0003-4502-1748
Rita LombardiExperimental Animal Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.
Hagos Tesfay MedhinNuclear Medicine Unit, Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0000-0002-0390-6006
Edom SeifeRadiotherapy Center, College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia.
Elena Di GennaroExperimental Pharmacology Unit, Laboratory of Naples and Mercogliano (AV), Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0001-6223-7845
Alfredo BudillonScientific Directorate, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0002-6330-6053
Gurja Belay WoldemichaelDepartment of Microbial Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0000-0001-7349-9218

Funding

International Atomic Energy Agency ETH/6023Ministero della Salute RC2024 L2/2
6 · The paper itself

Abstract

backgroundIonizing radiation (IR) exposure poses a significant health risk due to its widespread use in medical diagnostics and therapeutic applications, necessitating rapid and effective biomarkers for assessment.

objectiveThe aim of this study is to identify the serum proteomic signature of IR exposure in patients undergoing radiotherapy (RT).

methodsBlood samples were obtained from eighteen patients with head and neck cancer (HNC) and five patients with rectal cancer before and immediately after they underwent curative intensity-modulated radiotherapy (IMRT). The comprehensive serum proteome was analyzed in individual samples using nanoHPLC-MS/MS.

resultsForty radiation-modulated proteins (RMPs), 24 upregulated and 16 downregulated, with a fold change ≥1.5 and

Indexed as

biomarkerhead and neck cancerionizing radiationradiotherapyserum proteomics

Identifiers

PMID40149344
PMCPMC11940482

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.