Evidence map›Paper›PMID 40149339›Full record

ArticleCancers2025

Prolonged Diagnostic Interval Leads to High Lymphoma Related Mortality in a Prospective Cohort of People with HIV Undergoing Fine Needle Aspiration.

Samantha L Vogt, Khuthadzo Hlongwane, Arshia Arora, Kennedy Otwombe, Deshan Chetty, Rebecca H Berhanu, Ziyaad Waja, Wendy Stevens, Tanvier Omar, Neil A Martinson and 2 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha L VogtDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7597-8861
Khuthadzo HlongwanePerinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Arshia AroraDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Kennedy OtwombePerinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Deshan ChettyPerinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Rebecca H BerhanuDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Centre, Nashville, TN 37232, USA.
Ziyaad WajaPerinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.ORCID 0000-0001-8717-9039
Wendy StevensWits Diagnostic Innovation Hub, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Tanvier OmarDivision of Anatomical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.ORCID 0000-0001-7636-7616
Neil A MartinsonDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Richard F AmbinderDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4027-3073
Rena R XianDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
ONCOLOGY: CHEMOTHERAPY, IMMUNOLOGY, BIOLOGYT32CA009071 · NCI · JOHNS HOPKINS UNIVERSITY · PI Mary Y Armanios, Nilofer S. Azad · 1985 to 2026
$12.8M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Hodgkin Lymphoma in PLWH in South Africa: TB, EBV, and Tumor Molecular MarkersR01CA250069 · NCI · JOHNS HOPKINS UNIVERSITY · PI AMBINDER, RICHARD FREDERICK, XIAN, RENA · 2020 to 2024
$4.3M
Clonal Immunoglobulin DNA and Lymphoma DiagnosisR21CA232891 · NCI · JOHNS HOPKINS UNIVERSITY · PI AMBINDER, RICHARD FREDERICK, XIAN, RENA · 2020 to 2021
$317k
AIDS Malignancy Consortium UM1CA121947FIC NIH HHS R25 TW009340FIC NIH HHS R25TW009340NCI NIH HHS 5T32CA09071NCI NIH HHS P30AI094189NCI NIH HHS P30 CA006973NCI NIH HHS P30CA006973NCI NIH HHS R01 CA250069NCI NIH HHS R01CA250069NCI NIH HHS R21 CA232891NCI NIH HHS R21CA232891NCI NIH HHS T32 CA009071NCI NIH HHS UM1 CA121947NIAID NIH HHS P30 AI094189
6 · The paper itself

Abstract

backgroundHIV is associated with an increased risk of aggressive lymphomas. Lymphadenopathy is common at the time of presentation; therefore, we set out to understand the time to lymphoma diagnosis in people with HIV (PWH) undergoing fine needle aspiration (FNA).

methodsA prospective, observational cohort of PWH, age ≥ 18 years, undergoing FNA in Soweto, South Africa was established between September 2021 and December 2022. Participants were followed up for up to 8 months and provided consent for a medical record review.

resultsOne hundred and forty-six participants were enrolled, including 76 females (52%) with a median age of 40 years and a median CD4 count of 216 cells/μL. TB was the most common diagnosis (

conclusionsWhile TB was the most common diagnosis among PWH undergoing FNA, lymphoma was the leading cause of death. As most deaths occurred prior to chemotherapy, interventions to expedite a lymphoma diagnosis in this high-risk population are needed.

Indexed as

fine needle aspirationHIVlymphomamortalitytuberculosis

Identifiers

PMID40149339
PMCPMC11941734

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Registered trials

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