Evidence map›Paper›PMID 40149328›Full record

ArticleCancers2025

Axl Regulation of NK Cell Activity Creates an Immunosuppressive Tumor Immune Microenvironment in Head and Neck Cancer.

Kourtney L Kostecki, Regan L Harmon, Mari Iida, Madelyn A Harris, Bridget E Crossman, Justine Yang Bruce, Ravi Salgia, Deric L Wheeler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kourtney L KosteckiDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0003-2289-5194
Regan L HarmonDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0009-0001-6378-7299
Mari IidaDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0001-7168-8680
Madelyn A HarrisDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
Bridget E CrossmanDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0009-0006-8274-9104
Justine Yang BruceDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0002-5902-7430
Ravi SalgiaDepartment of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0001-9643-7626
Deric L WheelerDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0001-5915-3675

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Project 3: Modulation of the head and neck tumor immune microenvironment by targeting the TAM family of receptorsP50CA278595 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI David J Beebe · 2022 to 2026
$12.5M
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NCI NIH HHS P50 CA278595NIH HHS 5P50CA278595-08S24NIH HHS P30CA014520NIH HHS S10 OD023526NIH HHS S10OD023526
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Axlhead and neck cancerimmunosuppressionNK cellstumor microenvironment

Identifiers

PMID40149328
PMCPMC11940164

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.