Evidence map›Paper›PMID 40149307›Full record

ReviewCancers2025

Advancements in Assessing Pathological Fracture Risk: News on Mirels' Score.

Cesare Meschini, Alessandro El Motassime, Omar El Ezzo, Antonio Ziranu, Giulio Maccauro, Raffaele Vitiello

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Fibrous dysplasia: clinical and pathologic characteristics, surgical approaches, and outcomes in a large Italian cohort.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cesare MeschiniDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Alessandro El MotassimeDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0009-0001-8331-0826
Omar El EzzoDepartment of Orthopedics and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Antonio ZiranuOrthopedics and Traumatology, Università Cattolica Del Sacro Cuore, 00168 Roma, Italy.
Giulio MaccauroDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Raffaele VitielloDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0003-2321-9665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mirels' score is a widely utilized tool for assessing the risk of pathological fractures in patients with metastatic bone disease. This scoring system assists clinicians in estimating fracture likelihood based on clinical, radiological, and anatomical parameters, thereby guiding treatment decisions and management strategies. This review provides a comprehensive analysis of the Mirels' score, detailing its development, clinical applications, and its role in predicting fractures across various metastatic cancers. Additionally, it discusses the score's limitations, including its potential to over- or underestimate fracture risk, and explores recent advancements in imaging and biomarker technologies that may enhance or complement its predictive accuracy. By critically examining the existing literature, this review aims to offer a thorough understanding of the Mirels' score's strengths and weaknesses, while considering its future role in personalized cancer care.

Indexed as

femur fractureimpendingMirels’oncologicpathologicscore

Identifiers

PMID40149307
PMCPMC11941509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.