Evidence map›Paper›PMID 40149272›Full record

ArticleCancers2025

Segmentectomy Versus Wedge Resection for Stage IA Lung Adenocarcinoma-A Population-Based Study.

Xu-Heng Chiang, Chih-Fu Wei, Ching-Chun Lin, Mong-Wei Lin, Chun-Ju Chiang, Wen-Chung Lee, Jin-Shing Chen, Pau-Chung Chen

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In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xu-Heng ChiangDepartment of Medical Education, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0001-9025-8782
Chih-Fu WeiDepartment of Environmental and Occupational Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin 64041, Taiwan.
Ching-Chun LinInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University Hospital, Taipei 100025, Taiwan.
Mong-Wei LinDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100233, Taiwan.ORCID 0000-0003-1268-3729
Chun-Ju ChiangInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 106319, Taiwan.ORCID 0000-0002-1330-5319
Wen-Chung LeeInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 106319, Taiwan.ORCID 0000-0003-3171-7672
Jin-Shing ChenDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100233, Taiwan.
Pau-Chung ChenInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University Hospital, Taipei 100025, Taiwan.ORCID 0000-0002-6242-5974

Funding

National Health Research Institutes NHRI-EM-113-PP-01National Health Research Institutes NHRI-EM-114-GP-02National Health Research Institutes NHRI-EM-114-GP-03National Science and Technology Council NSTC-112-2621-M-002-024-MY3National Science and Technology Council NSTC-113-2314-B-002-308-MY3National Science and Technology Council NSTC-113-2621-M-002-019National Taiwan University Hospital 114-M0034
6 · The paper itself

Abstract

backgroundSublobar resection (SLR), including segmentectomy and wedge resection (WR), is an alternative to lobectomy for early-stage lung cancer due to its potential benefits in preserving lung function. However, the comparative outcomes between segmentectomy and WR for stage IA lung adenocarcinoma are equivocal. This population-based study aimed to compare overall survival between segmentectomy and WR.

methodsData on patients with clinical stage IA lung adenocarcinoma were collected from the Taiwan Cancer Registry between 2011 and 2018. The primary endpoint was overall survival. Further subgroup survival analyses were conducted based on tumor size. Propensity score matching (PSM) was used to balance baseline differences such as age and tumor stage between the two groups. Predictors of survival other than the surgical procedure were analyzed using a Cox regression model.

resultsIn total, 6598 patients with stage IA lung adenocarcinoma undergoing SLR between 2011 and 2018 were enrolled, including 2061 and 4537 receiving segmentectomy and WR, respectively. The mean age was 60.3 ± 11.7 years, 66.2% were female, and 81.5% never smoked. After PSM, segmentectomy was associated with significantly better overall survival than WR (

conclusionsSegmentectomy offered superior overall survival for patients with tumors larger than 2 cm. For tumors smaller than 2 cm, the outcomes of segmentectomy and WR were comparable, offering flexibility in surgical decision-making. These findings highlight the need for individualized surgical approaches based on tumor characteristics.

Indexed as

lung adenocarcinomanon-small cell lung cancer (NSCLC)population-basedsegmentectomysublobar resectionwedge resection

Identifiers

PMID40149272
PMCPMC11940408

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