Evidence map›Paper›PMID 40149257›Full record

ArticleCancers2025

The Chimeric Antigen Receptor T Cell Target Claudin 6 Is a Marker for Early Organ-Specific Epithelial Progenitors and Is Expressed in Some Pediatric Solid Tumor Entities.

Larissa Seidmann, Arthur Wingerter, Marie Oliver Metzig, Angelina Bornas, Khalifa El Malki, Arsenij Ustjanzew, Franziska Ortmüller, Yevgeniy Kamyshanskiy, Thomas Kindler, Mark Laible and 9 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Larissa SeidmannInstitute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Arthur WingerterDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Marie Oliver MetzigInstitute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Angelina BornasDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Khalifa El MalkiDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Arsenij UstjanzewInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.ORCID 0000-0002-1014-4521
Franziska OrtmüllerDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Yevgeniy KamyshanskiyInstitute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Thomas KindlerUniversity Cancer Center (UCT), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Mark LaibleBioNTech SE, 55131 Mainz, Germany.ORCID 0000-0002-5548-6402
Xenia MohrDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Nicole HenningerDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Alexandra RussoDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Olaf BeckDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Francesca AltDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Pia WehlingDepartment of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Wilfried RothInstitute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Claudia ParetHelmholtz-Institute for Translational Oncology Mainz (HI-TRON), 55131 Mainz, Germany.ORCID 0000-0002-9094-1634
Jörg FaberHelmholtz-Institute for Translational Oncology Mainz (HI-TRON), 55131 Mainz, Germany.ORCID 0000-0002-5432-8234

Funding

HI-TRON HITR-2021-14Stiftung Kinderkrebsforschung Mainz SKFM_01_2022
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CAR-T cellsClaudin 6desmoplastic small round cell tumorsgerm cell tumorsWilms tumors

Identifiers

PMID40149257
PMCPMC11940025

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.