Evidence map›Paper›PMID 40149204›Full record

ArticleEntropy (Basel, Switzerland)2025

The Reasonable Ineffectiveness of Mathematics in the Biological Sciences.

Seymour Garte, Perry Marshall, Stuart Kauffman

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From episodes to populations: evolutionary explanation requires a constructive epistemology.Theory in biosciences = Theorie in den Biowissenschaften · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seymour GarteDepartment Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-3284-5975
Perry MarshallEvolution 2.0, Oak Park, IL 60301, USA.ORCID 0000-0003-2876-8583
Stuart KauffmanThe Institute for Systems Biology, Seattle, WA 98109-5263, USA.ORCID 0000-0001-7094-4312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The known laws of nature in the physical sciences are well expressed in the language of mathematics, a fact that caused Eugene Wigner to wonder at the "unreasonable effectiveness" of mathematical concepts to explain physical phenomena. The biological sciences, in contrast, have resisted the formulation of precise mathematical laws that model the complexity of the living world. The limits of mathematics in biology are discussed as stemming from the impossibility of constructing a deterministic "Laplacian" model and the failure of set theory to capture the creative nature of evolutionary processes in the biosphere. Indeed, biology transcends the limits of computation. This leads to a necessity of finding new formalisms to describe biological reality, with or without strictly mathematical approaches. In the former case, mathematical expressions that do not demand numerical equivalence (equations) provide useful information without exact predictions. Examples of approximations without equal signs are given. The ineffectiveness of mathematics in biology is an invitation to expand the limits of science and to see that the creativity of nature transcends mathematical formalism.

Indexed as

mathematical lawsset theorythird transition

Identifiers

PMID40149204
PMCPMC11941032

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.