SynthesisOrphanet journal of rare diseases2025
Epidemiology of gall bladder cancer and its prevalence worldwide: a meta-analysis.
Synthesis in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer.Cancer reports (Hoboken, N.J.) · 2026Review
- Prognostic implications and precision selection criteria of primary tumor resection in metastatic gallbladder adenocarcinoma.Discover oncology · 2026Article
- Predictors and reasons for conversion of laparoscopic to open cholecystectomy: a five-year cohort study.Surgical endoscopy · 2026Article
- Actionable genomic landscape of biliary tract cancer in the Indian population.The oncologist · 2026Article
- Identification of differentially expressed genes and associated immune cell types in South African gallbladder cancer patients.Scientific reports · 2025Article
- Current insights and future perspectives of treatment strategies for biliary tract cancer.World journal of gastrointestinal oncology · 2025Review
- Diagnostic Utility of Serum CEA and Ca 19.9 as Triage Tools for Predicting Metastatic Disease in Gallbladder Cancer: A Sub-analysis from a Prospective Observational Study.Journal of gastrointestinal cancer · 2025Observational
- Article
- Trends and projections of gallbladder and biliary tract cancer in China: a comprehensive analysis from 1990 to 2030 based on the Global Burden of Disease Study 2021.BMC public health · 2025Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGallbladder carcinoma (GBC) accounts for 1.3% of cancer incidence and 1.7% of cancer-related deaths which emphasizes the need for comprehensive research in epidemiological trends.
aimWe aim to address this gap by investigating global prevalence trends across various regions, age groups, risk factors and cancer stages.
methodsA meta-analysis of studies retrieved from Google Scholar, PubMed and Web of Science, reporting prevalence of GBC was conducted using a predetermined screening criterion. Meta Regression and Egger's Regression-based tests were employed to assess heterogeneity and publication bias, respectively.
resultsWe identified three types of studies (n = 20), primarily originating from Asia (n = 10) over a cumulative time period of 24 years (1988-2012). The pooled analysis revealed a statistically significant GBC prevalence of 20.3 ± 5.2% (95% CI 9.3-31.3%, p = 0.001) among at-risk populations, including those with gallstones or cholecystitis. Analysis of potential publication bias showed none, nevertheless, individual parameters indicated varying significance. Subgroup analyses highlighted regional, temporal, and demographic variations, emphasizing the influence of factors like sample size and age on GBC prevalence. Correlation analysis demonstrated strong positive associations with sample size (p < 0.01), gender distribution (male: r = 0.85, p < 0.01, female: r = 0.806, p < 0.01), and prevalence rates (r = 0.98, p = 0.04).
conclusionDespite of less data present, our comprehensive overview of prevalence, regional variations, and demographic associations serves as a crucial starting point for future targeted investigations. The study fulfills a gap in epidemiology of GBC and emphasizes the need for increased attention and provides a pioneering arena in future.
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