Trial reportJournal of neuroengineering and rehabilitation2025
Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Transcranial Alternating Current Stimulation for Major Depressive Disorder and the Role of Intensity: A Systematic Review and Exploratory Meta-Analysis.Alpha psychiatry · 2026Pooled it
- Neurophysiological effects of transcranial alternating current stimulation combined with multidisciplinary rehabilitation in Parkinson's disease.Frontiers in psychiatry · 2026Trial
- Effect of robot-assisted gait training combined with electroacupuncture on lower limb motor function and brain network characteristics in stroke: an EEG study.Journal of neuroengineering and rehabilitation · 2025Trial
- Online modulation of neural drive to lower motor neurons with high-definition transcranial alternating current stimulation (HD-tACS).Journal of neuroengineering and rehabilitation · 2026Article
- Canonical coherence for the estimation of within- and cross-frequency cortico-kinematic interactions.Scientific reports · 2026Article
- The Relationship Between the Cortico-Diaphragmatic Conduction Pathway and Cardiopulmonary Function in Healthy Individuals.The clinical respiratory journal · 2026Article
- Correction: Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.Journal of neuroengineering and rehabilitation · 2025Article
- EEG activity over ipsilateral and contralateral M1 during simple and complex hand tasks: variations with motor learning.Frontiers in neuroscience · 2025Article
- rTMS-induced neuroimaging changes measured with structural and functional MRI in autism.Frontiers in neuroscience · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
backgroundTranscranial alternating current stimulation (tACS) is a non-invasive technique that modulates neural oscillations, yet its specific effects on cortical excitability are not well-understood. This study investigated the effects of tACS on neuroplasticity in the primary motor cortex (M1) across different frequencies.
methodsIn this randomized, sham-controlled, crossover study, 18 healthy young adults received β-tACS γ-tACS, and sham stimulation over the M1. Neurophysiological responses were assessed using motor evoked potentials (MEPs), electroencephalograms (EEG), and transcranial evoked potentials (TEPs) to determine the frequency-specific effects of tACS on cortical excitability and neuroplasticity.
resultsγ-tACS significantly enhanced cortical excitability, as reflected by larger MEP amplitudes compared to both β-tACS and sham stimulation. In addition, γ-tACS resulted in significantly smaller M1-P15 amplitudes in TEP than other stimulation conditions. In contrast, β-tACS did not produce significant changes in either MEPs or TEPs compared to sham stimulation.
conclusionThese findings provide evidence that tACS induces frequency-dependent effects on cortical excitability and neuroplasticity within the M1. This selective modulation of cortical excitability with γ-tACS suggests its potential as a therapeutic intervention for optimizing motor function and rehabilitation.
trial registrationThis study was registered in the Chinese Clinical Trial Registry (ChiCTR2300074898, date of registration: 2023/08/18).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.