ArticleLipids in health and disease2025
Systemic inflammation response index mediates the association between relative fat mass and psoriasis risk: a population-based study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Associations of Anthropometric Indices With Stages and Mortality in Cardiovascular-Kidney-Metabolic Syndrome: Insights From NHANES.Reviews in cardiovascular medicine · 2026Article
- The predictive value of baseline systemic inflammation response index and systemic immune-inflammation index for the risk of infection within 6 months following initial immunosuppressive treatment in patients with ANCA-associated vasculitis.Frontiers in immunology · 2026Article
- Skin Care Supports Overall Well-Being.Clinical, cosmetic and investigational dermatology · 2025Article
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7 authors.
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Abstract
backgroundPsoriasis, a prevalent autoimmune skin condition, considerably impairs the quality of life of those who are affected by it. Several studies have demonstrated that obesity significantly contributes to both the onset and progression of psoriasis. Relative fat mass (RFM), a novel obesity index, provides a more precise measure by incorporating both height and waist circumference (WC). The aim of this study was to investigate the association between RFM and psoriasis risk, taking into account the intermediary role played by the systemic inflammation response index (SIRI).
methodsThe cross-sectional study assessed data from 8,479 adults who participated in the NHANES cycles from 2003 to 2006 and 2009 to 2014. To examine the association between RFM and psoriasis, both multivariate logistic regression model and restricted cubic spline (RCS) analyses were conducted. A mediation analysis was used to clarify the role of SIRI in the association between RFM and psoriasis.
resultsHigher RFM was significantly associated with a 5% higher risk of developing psoriasis (odds ratio [OR] = 1.05, 95% confidence interval [CI]:1.02-1.08), with RFM quartiles indicating a significant trend (P
conclusionElevated RFM are associated with an increased prevalence of psoriasis. RFM has the potential to be a beneficial anthropometric measure for more accurately predicting psoriasis risk.
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