Evidence map›Paper›PMID 40148864›Full record

ReviewJournal of translational medicine2025

The mechanisms and applications of endothelial progenitor cell therapy in the treatment of intracranial aneurysm.

Shiyu Shen, Tonglin Pan, Peixi Liu, Yanlong Tian, Yuan Shi, Wei Zhu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shiyu Shen *Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Tonglin Pan *Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Peixi LiuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yanlong TianDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yuan ShiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. yuanshi18@fudan.edu.cn.ORCID http://orcid.org/0000-0002-4571-4424
Wei ZhuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. drzhuwei@fudan.edu.cn.ORCID http://orcid.org/0000-0001-7190-7476

Funding

Clinical Research Plan of SHDC SHDC2020CR2034BNational Natural Science Foundation of China 82171311National Natural Science Foundation of China 82201462National Natural Science Foundation of China 82271339National Natural Science Foundation of China 82301489National Natural Science Foundation of China 82330039Shanghai Excellent Academic Leader Program 21XD1400600Shanghai Municipal Health Commission 2022ZZ01006Shanghai Municipal Health Commission GWVI-11.1-17Shanghai Sailing Program 23Y1404500Special Clinical Research Project in Health Industry of Shanghai Municipal Health Commission 20224Y0072
6 · The paper itself

Abstract

The pathophysiological mechanism of intracranial aneurysm (IA) involves the dynamic interaction of ECM abnormalities, hemodynamic stress, and inflammatory response. The rupture of intracranial aneurysm will cause serious consequences. Multiple studies have confirmed the important role and potential application of endothelial progenitor cells (EPCs) in vascular repair. This review focuses on the specific mechanism of EPCs in the treatment of intracranial aneurysms, which promote re-endothelialization and angiogenesis through bone marrow mobilization, targeted migration to the site of injury, differentiation into mature endothelial cells, and secretion of angiogenic factors. In addition, EPCs maintain ECM homeostasis by regulating MMP/IMP balance, inhibiting aneurysm wall thinning and structural damage. Based on the vascular repair mechanism of EPCs, new treatment strategies such as "biologically active" spring coils (loaded with EPCs or SDF-1α) and flow diverters(FDs) combined with EPCs therapy have been developed to synergistically promote carotid endothelialization of aneurysms and reduce the risk of recurrence. Future research needs to further validate the long-term efficacy and precise regulatory mechanisms of EPCs in clinical translation, providing new directions for IA treatment.

Indexed as

Endothelial Progenitor CellsIntracranial AneurysmStem Cell TransplantationAnimalsHumansEndothelializationEndothelial progenitor cellEndovascular treatmentIntracranial aneurysm

Identifiers

PMID40148864
PMCPMC11951544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.