Evidence map›Paper›PMID 40148790›Full record

ArticleBMC psychiatry2025

Smoking impairs cognitive function through the mediating effect of periodontitis in older adults.

Xiaoqian Luan, Zhou Jin, Shenhang Xia, Jin Li, Yao An, Jiaqi Gao, Shengya Wang, Huwei Xia, Sipei Pan, Yao Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoqian Luan *Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Zhou Jin *Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), 999 Jinshi Road, Yongzhong Street, Longwan District, Wenzhou, 325035, Zhejiang Province, China.
Shenhang XiaInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Jin LiInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Yao AnInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Jiaqi GaoInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Shengya WangInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Huwei XiaInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Sipei PanInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Yao ZhangOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), 999 Jinshi Road, Yongzhong Street, Longwan District, Wenzhou, 325035, Zhejiang Province, China.
Weihong SongInstitute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Center for Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. weihong@wmu.edu.cn.
Yili WuWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Zhejiang Provincial Clinical Research Center for Mental Health, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. wuyili@wmu.edu.cn.ORCID 0000-0002-2369-6974

Funding

the National Natural Science Foundation of China No. 82150710557 and 82293642
6 · The paper itself

Abstract

objectivesEvidence has shown that both smoking and periodontitis were linked to cognitive impairment. This study examines whether periodontitis mediates the effects of smoking status on cognitive function in older adults.

methodsUsing data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, the study included 1728 older participants who have data on smoking, serum cotinine, periodontal examination, and cognitive function. Mediation analysis was performed to test whether extent of periodontitis mediated associations between smoking status and cognitive function, adjusted for sociodemographic and basic health factors.

resultsCompared to never-smokers, daily smokers exhibited significantly worse global cognitive function, with periodontitis mediating this effect (effect= -0.16; 95% CI= -0.29, -0.05). Similarly, periodontitis mediated the association between serum cotinine levels and cognitive function in the total sample (effect= -0.02; 95% CI= -0.03, -0.00).

conclusionsPeriodontitis significantly mediates the impact of smoking on cognitive function. The findings highlight the potential roles of maintaining oral health and smoking cessation in mitigating cognitive decline.

Indexed as

CognitionCognitive DysfunctionPeriodontitisSmokingAgedCotinineFemaleHumansMaleMediation AnalysisMiddle AgedNutrition SurveysCotinineCognitive functionMediationNHANESPeriodontitisSmoking

Identifiers

PMID40148790
PMCPMC11948936

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.