Evidence map›Paper›PMID 40148720›Full record

SynthesisBrain imaging and behavior2025

Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis.

Tingting Zhu, Jing Chen, Yanting Du, Tongyue Li, Xize Jia, Yating Lv

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tingting ZhuCenter for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, Hangzhou, Zhejiang, 311121, China.ORCID https://orcid.org/0000-0002-5414-9842
Jing ChenCenter for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, Hangzhou, Zhejiang, 311121, China.ORCID https://orcid.org/0000-0002-1191-0697
Yanting DuSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, Heilongjiang, 154007, China.ORCID https://orcid.org/0000-0002-2666-2921
Tongyue LiCenter for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, Hangzhou, Zhejiang, 311121, China.ORCID https://orcid.org/0009-0004-4381-9814
Xize JiaCenter for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, Hangzhou, Zhejiang, 311121, China.ORCID https://orcid.org/0000-0001-8374-5582
Yating LvCenter for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, Hangzhou, Zhejiang, 311121, China. lvyating198247@gmail.com.ORCID https://orcid.org/0000-0002-5547-3361

Funding

National Natural Science Foundation of China 82001898 and 8207070625Zhejiang Medical and Health Science and Technology Project 2021KY249Zhejiang Provincial Natural Science Foundation of China LGJ22H180001
6 · The paper itself

Abstract

This study aims to unravel the consistent abnormalities in functional connectivity (FC) with the primary motor cortex (M1) for post-stroke motor dysfunctions and the dynamic shifts of FC across distinct phases (acute/subacute/chronic) following stroke onset. Eleven studies with 269 stroke patients and 257 healthy controls (HCs) were included after screening articles in PubMed, Web of Science, and Embase. Voxel-wise meta-analysis and subgroup analysis on three phases after stroke onset were applied using the anisotropic effect size-signed differential mapping toolbox. Additionally, a M1-seeded FC analysis from an independent dataset with 29 stroke patients and 40 HCs was applied to validate the results of the meta-analyses. The abnormal connectivity with M1 in patients with post-stroke motor dysfunctions extended beyond motor-related regions to non-motor domains. A consistent interhemispheric connectivity reduction between M1 and motor-related regions emerged as a hallmark, persisting across different phases after stroke onset. These alterations were largely replicable through validation analysis. Our findings indicated the imbalance of connectivity in patients with post-stroke motor dysfunctions.

Indexed as

Motor CortexStrokeBrainBrain MappingHumansMagnetic Resonance ImagingNeural PathwaysRestFunctional connectivityPost-stroke motor dysfunctionsPrimary motor cortexResting-state fMRIStroke

Identifiers

PMID40148720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.