ArticleSurgery today2025
Appendectomy followed by two-stage right-sided colectomy with lymph node dissection for appendiceal cancer and risk factors for peritoneal recurrence: a single high-volume cancer center study in Japan.
Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Are the long-term oncologic outcomes different between appendiceal cancer and right-sided colon cancer? An exact matching analysis of a 10-year institutional cohort.Annals of surgical treatment and research · 2026Article
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8 authors.
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Abstract
purposeFew studies have evaluated whether the timing of colectomy affects the prognosis of appendiceal cancer. This study compared long-term outcomes and recurrence patterns between initial appendectomy followed by two-stage colectomy and one-stage colectomy for appendiceal cancer.
methodsWe retrospectively evaluated 65 patients who underwent 2-stage (n = 17) or 1-stage (n = 48) right-sided colectomy with lymph node dissection for stage 0-III appendiceal cancer between August 2005 and December 2022. The recurrence types and risk factors were compared.
resultsThe 2-stage colectomy group had a more advanced disease stage than the 1-stage group (stage III cases: 29.4% vs. 14.6%, P = 0.03). The 5-year overall recurrence rates were similar between the groups (29.4% vs. 19.2%, P = 0.39). All peritoneal recurrence cases (n = 9) had pT3 or T4 depth. Among pT3 and T4 cases (n = 46), the peritoneal recurrence rates did not differ significantly (31.2% vs. 13.8%, P = 0.17). A multivariate analysis identified preoperative serum CA19-9 level of > 37 ng/mL (hazard ratio [HR], 35.4; 95% confidence interval [CI], 3.08-406.8; P = 0.004) and lymph node metastasis (HR, 42.6; 95% CI, 9.90-183.6; P < 0.001) as independent risk factors for peritoneal recurrence.
conclusionsSerum CA19-9 levels and lymph node metastasis are risk factors for peritoneal recurrence. The effect of colectomy timing on recurrence was not definitive.
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