Evidence map›Paper›PMID 40148566›Full record

ArticleNature microbiology2025

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii.

Julia N Eberhard, Lindsey A Shallberg, Aaron Winn, Sambamurthy Chandrasekaran, Christopher J Giuliano, Emily F Merritt, Elinor Willis, Christoph Konradt, David A Christian, Daniel L Aldridge and 7 more

Abstract read
In one paragraph

Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Getting on your last nerve: IFNs and resistance to infection.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  4. Article
  5. Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026
    Review
  6. LatentBiomolecules · 2025
    Article
  7. Article
  8. Toxoplasma gondii and the Brain: Frenemies? Or Just Outright Foes?Journal of the Pediatric Infectious Diseases Society · 2025
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Julia N Eberhard *Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lindsey A Shallberg *Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6573-7327
Aaron Winn *Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0441-9189
Sambamurthy ChandrasekaranBIO5 Institute, University of Arizona, Tucson, AZ, USA.
Christopher J GiulianoWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0586-6095
Emily F MerrittDepartment of Immunology, University of Arizona, Tucson, AZ, USA.
Elinor WillisComparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Christoph KonradtDepartment of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA.
David A ChristianDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Daniel L AldridgeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2224-5159
Molly E BunkofskeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1457-5641
Maxime JacquetDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Florence DzierszinskiThe Royal Ottawa Mental Health Center, Institute of Mental Health Research, Ottawa, Ontario, Canada.
Eleni KatiforiDepartment of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7332-4749
Sebastian LouridoWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5237-1095
Anita A KoshyBIO5 Institute, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0001-8705-3233
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. chunter@vet.upenn.edu.ORCID http://orcid.org/0000-0003-3092-1428

Funding

IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
Neuronal Latency and ToxoplasmaR01AI157247 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOPHER A HUNTER, Anita Koshy · 2020 to 2026
$4.7M
Development and maintenance of chronic toxoplasmosisR01AI158501 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2021 to 2025
$3.3M
Mechanisms of combined CD40/TLR adjuvant-elicited cellular immunityU01AI160664 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ADAMS, THOMAS A, HUNTER, CHRISTOPHER A · 2021 to 2025
$3.1M
Impact of IL-27 on monocyte responses to Toxoplasma gondii infectionF31AI161962 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALDRIDGE, DANIEL · 2022 to 2024
$131k
NCI NIH HHS T32 CA009140NIAID NIH HHS F31 AI161962NIAID NIH HHS R01 AI157247NIAID NIH HHS R01 AI158501NIAID NIH HHS U01 AI160664
6 · The paper itself

Abstract

Latency is a microbial strategy for persistence. For Toxoplasma gondii the bradyzoite stage forms long-lived cysts critical for transmission, and its presence in neurons is considered important for immune evasion. However, the extent to which cyst formation escapes immune pressure and mediates persistence remained unclear. Here we developed a mathematical model highlighting that bradyzoite-directed immunity contributes to control of cyst numbers. In vivo studies demonstrated that transgenic CD8

Indexed as

ToxoplasmaToxoplasmosisAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalHost-Parasite InteractionsMiceMice, Inbred C57BLModels, TheoreticalSTAT1 Transcription FactorToxoplasmosis, AnimalStat1 protein, mouseSTAT1 Transcription Factor

Identifiers

PMID40148566
PMCPMC11964939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.