Evidence map›Paper›PMID 40148508›Full record

ArticleScientific reports2025

In vitro enzymatic and cell culture assays for SARS-CoV-2 main protease interaction with ambenonium.

Juliana Ângelo de Souza, Isabela de Souza Gomes, Luciana de Souza Fernandes, Luis Adan Flores Andrade, Luciana Ângelo de Souza, Vinícius de Almeida Paiva, Sheila Cruz Araujo, Leonardo Henrique Franca de Lima, Roberto Sousa Dias, Raquel Cardoso de Melo-Minardi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juliana Ângelo de SouzaDepartment of Computer Science, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil. juliana.angelo@ufv.br.
Isabela de Souza GomesDepartment of Computer Science, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Luciana de Souza FernandesDepartment of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Luis Adan Flores AndradeCentro de Tecnologia de Vacinas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Luciana Ângelo de SouzaDepartment of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Vinícius de Almeida PaivaDepartment of Computer Science, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Sheila Cruz AraujoDepartment of Bioinformatics, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.
Leonardo Henrique Franca de LimaDepartment of Exact and Biological Sciences, Universidade Federal de São João del-Rei, Sete Lagoas Campus, Sete Lagoas, Minas Gerais, Brazil.
Roberto Sousa DiasDepartment of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Raquel Cardoso de Melo-MinardiDepartment of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Flávio Guimarães da FonsecaCentro de Tecnologia de Vacinas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Sérgio Oliveira de PaulaDepartment of Microbiology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Sabrina de Azevedo SilveiraDepartment of Computer Science, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00567-18
6 · The paper itself

Abstract

The 2019 pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 led to millions of deaths worldwide since its emergence. The viral genomic material can code structural and non-structural proteins including the main protease or 3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesSARS-CoV-2COVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationProtein BindingVirus ReplicationAntiviral AgentsCoronavirus 3C ProteasesAmbenoniumDrug repurposingIn vitro assayMain proteaseModulation activityPandemicSARS-CoV-2

Identifiers

PMID40148508
PMCPMC11950299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.