Evidence map›Paper›PMID 40148479›Full record

ArticleNPJ digital medicine2025

Leveraging electronic medical records to evaluate a computerized decision support system for staphylococcus bacteremia.

Julia Palm, Ssuhir Alaid, Danny Ammon, Julian Brandes, Andreas Dürschmid, Claudia Fischer, Jonas Fortmann, Kristin Friebel, Sarah Geihs, Anne-Kathrin Hartig and 41 more

Abstract read
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In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Julia PalmInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany. julia.palm@med.uni-jena.de.ORCID http://orcid.org/0000-0003-1568-5893
Ssuhir AlaidIT Department, Data Integration Center, University Hospital Halle, Halle, Germany.
Danny AmmonData Integration Center, Jena University Hospital, Jena, Germany.
Julian BrandesCenter for Medical Informatics, Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
Andreas DürschmidCenter for Medical Informatics, Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
Claudia FischerInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Jonas FortmannInstitute of Medical Informatics, University Hospital RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0003-1757-525X
Kristin FriebelInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Sarah GeihsIT Department, Data Integration Center, University Hospital Aachen, Aachen, Germany.
Anne-Kathrin HartigIT Department, Data Integration Center, University Hospital Halle, Halle, Germany.
Donghui HeCentral IT Department, Data Integration Center, University Hospital Essen, Essen, Germany.
Andrew J HeidelData Integration Center, Jena University Hospital, Jena, Germany.
Petra HetfeldDepartment of Intensive Care Medicine and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany.
Roland IhleCentral IT Department, Data Integration Center, University Hospital Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-8502-7303
Suzanne KahleCenter for Medical Informatics, Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
Verena KoiCenter for Medical Informatics, Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
Margarethe KonikDepartment of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Frauke KretzschmannIT Department, Data Integration Center, University Hospital Aachen, Aachen, Germany.
Henner KruseData Integration Center, Jena University Hospital, Jena, Germany.
Norman LippmannInstitute for Medical Microbiology and Virology, University Hospital Leipzig, Leipzig, Germany.
Christoph LübbertDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, University Hospital Leipzig, Leipzig, Germany.
Gernot MarxDepartment of Intensive Care Medicine and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany.
Rafael MikolajczykInstitute of Medical Epidemiology, Biometrics, and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Germany.
Anne MlocekInstitute for Medical Microbiology and Virology, University Hospital Leipzig, Leipzig, Germany.
Stefan MoritzSection of Clinical Infectious Diseases, University Hospital Halle, Halle, Germany.ORCID http://orcid.org/0000-0001-9503-9642
Christoph MüllerIT Department, Data Integration Center, University Hospital Aachen, Aachen, Germany.
Susanne MüllerInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Ariadna Pérez GarrigaInstitute of Medical Informatics, University Hospital RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0001-8840-1770
Lo An Phan-VogtmannInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Diana PietznerIT Department, Data Integration Center, University Hospital Halle, Halle, Germany.
Mathias W PletzInstitute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
Mario PoppSection of Clinical Infectious Diseases, University Hospital Halle, Halle, Germany.
Maike RebenstorffInstitute for Medical Microbiology and Virology, University Hospital Leipzig, Leipzig, Germany.
Jonas RenzData Integration Center, Jena University Hospital, Jena, Germany.
Florian RißnerCenter for Clinical Studies, Friedrich-Schiller-University Jena, Jena, Germany.
Rainer RöhrigInstitute of Medical Informatics, University Hospital RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0002-0032-5118
Kutaiba SalehData Integration Center, Jena University Hospital, Jena, Germany.
Sebastian G SchönherrDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, University Hospital Leipzig, Leipzig, Germany.
Cord SpreckelsenInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Anja StempelDepartment of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Abel StolzCenter for Medical Informatics, Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
Eric ThomasData Integration Center, Jena University Hospital, Jena, Germany.
Susanne ThonInstitute of Medical Microbiology, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0009-0004-0254-2935
Daniel TillerIT Department, Data Integration Center, University Hospital Halle, Halle, Germany.
Sebastian UschmannInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
Sebastian WendtHospital Hygiene Staff Unit, University Hospital Halle (Saale), Halle, Germany.
Thomas WendtCenter for Medical Informatics, Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
Philipp WinnekensCentral IT Department, Data Integration Center, University Hospital Essen, Essen, Germany.
Oliver WitzkeDepartment of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Stefan Hagel *Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
André Scherag *Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.

Funding

Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ZZ1803BBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ZZ1803CBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ZZ1803DBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ZZ1803NBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ZZ1803P
6 · The paper itself

Abstract

Infectious disease specialists (IDS) improve outcomes of patients with Staphylococcus bacteremia, but immediate IDS access is not always guaranteed. We investigated whether a care-integrated computerized decision support system (CDSS) can safely enhance the standard of care (SOC) for these patients. We conducted a multicenter, noninferiority, interventional stepped-wedge cluster randomized controlled trial relying on the data integration centers at five university hospitals. By this means, electronic medical records can be used for part of the trial documentation. We analyzed 5056 patients from 134 wards (Staphylococcus aureus (SAB): n = 812, coagulase-negative staphylococci (CoNS): n = 4244) and found that the CDSS was noninferior to the SOC for hospital mortality in all patients. Noninferiority regarding the 90-day mortality/relapse in SAB patients was not observed and there was no evidence for differences in vancomycin usage among CoNS patients. Despite low reported usage, physicians rated the CDSS's usability favorably. Trial registration: drks.de; Identifier: DRKS00014320; Registration Date: 2019-05-06.

Identifiers

PMID40148479
PMCPMC11950190

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