Evidence map›Paper›PMID 40148456›Full record

ArticleScientific reports2025

A retrospective study of 17,995 patients investigating the location and recurrence of papillary thyroid cancer.

Peng Qi, Ziming Wang, Xu Hao, Xinyang Ou, Ben Zhang, Qi Shi, Kaixuan Li, Xuyao Liu, Zhen Wu, Shaoxiong Lu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peng Qi *Thyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Ziming Wang *Thyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Xu HaoThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Xinyang OuThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Ben ZhangThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Qi ShiThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Kaixuan LiThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Xuyao LiuThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Zhen WuSchool of Foreign Languages, Tianjin University, Tianjin, 300000, China.
Shaoxiong LuThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.
Qiang ZhangThyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China. zqiang@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of papillary thyroid cancer (PTC) has recently increased. Although PTC usually has a good prognosis, patients with advanced or localized metastases experience a high rate of recurrence. Although many studies have investigated PTC recurrence, a correlation between PTC location and recurrence remains unclear. Thus, we aimed to determine whether the location of PTC affects recurrence.Data were obtained from a single thyroid surgery center with > 6000 surgical cases per year. Between 2009 and 2022, 17,995 were enrolled in this study after screening. The location of the cancerous lesions was determined from ultrasound and pathology reports as well as the division of the lateral thyroid lobes into coronal and sagittal perspectives. The coronal plane was equally divided into upper, middle, and lower parts, and the sagittal plane was equally divided into anterior and dorsal aspects. Kaplan-Meier analysis and Cox proportional hazards regression models were used to analyze recurrence and risk factors. This study concluded that the upper part of the coronal plane and the dorsal part of the sagittal plane were most strongly associated with recurrence. Multifactorial analysis showed that lymph node metastatic status, multifocality, and superior and dorsal location of the tumor were significantly associated with PTC recurrence.

Indexed as

Neoplasm Recurrence, LocalThyroid Cancer, PapillaryThyroid NeoplasmsAdolescentAdultAgedFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedPrognosisProportional Hazards ModelsRetrospective StudiesRisk Factors

Identifiers

PMID40148456
PMCPMC11950511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.