Evidence map›Paper›PMID 40148447›Full record

ArticleScientific reports2025

Conserved marseilleviruses harboring diverse antibiotic resistance genes isolated from the Yangtze river Delta and the Pearl river delta, China.

Yucheng Xia, Baiyu Su, Hongwei Ren, Feifei Liu, Xiaojun Wang, Yue-Him Wong, Rui Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yucheng XiaCollege of Civil and Transportation Engineering, Shenzhen University, Shenzhen, 518060, China.
Baiyu SuArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Hongwei RenArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Feifei LiuArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Xiaojun WangArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Yue-Him WongArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Rui ZhangArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China. ruizhang@szu.edu.cn.

Funding

Innovation Team Project of Universities in Guangdong Province 2023KCXTD028National Natural Science Foundation of China 42406092
6 · The paper itself

Abstract

Marseilleviruses are a group of double-stranded DNA viruses infecting Acanthamoeba within the phylum Nucleocytoviricota and are ubiquitous in water and soil globally. Here, we report six strains of marseilleviruses isolated from environmental samples in the Yangtze River Delta and the Pearl River Delta, China. Viral particles exhibited icosahedral shaped capsids measuring about 220 ~ 240 nm in diameter. Based on stability assays, viral particles were halotolerant and acid-tolerant, but sensitive to chloroform and high temperature. Genomics and phylogenetic analyses showed that these strains were highly conserved compared with other reported marseilleviruses. Diverse members of the small multidrug resistance (SMR) family of transporter, which is a type of antibiotics resistance gene (ARG) and contribute to the feature of antibiotic resistance in bacteria, to our best knowledge, are firstly described in Marseilleviridae. The alignments of primary structures and in-silico tertiary structures reveal structural and potential functional similarity between giant viral and bacterial SMR, suggesting a possible role in viruses' interaction with antibiotics. The biological properties of marseillevirus and the discovery of viral SMR provide insight in the external and intracellular environment fitness of these large amoeba-infecting viruses.

Indexed as

DNA VirusesDrug Resistance, MicrobialRiversChinaGenome, ViralPhylogenyAmoebaAntibiotics resistance geneBiological propertyMarseillevirusSmall multidrug-resistance family of transporter

Identifiers

PMID40148447
PMCPMC11950327

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.