ArticleScientific reports2025
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Three novel Rothia species associated with Antarctic birds harbour novel biosynthetic gene clusters.FEMS microbiology ecology · 2026Article
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Authors and funding
8 authors.
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Abstract
A batch of sheep in a sheep farm in Xinjiang, China, died suddenly; a bacterial strain was isolated from the abdominal fluid of the sick and dead sheep, and identified as Rothia nasimurium by 16S sequencing, and the strain Y1 was subjected to drug sensitivity test with Draft gene sequencing. The results of the drug sensitivity test revealed the strain's resistance to 9 antibiotics, with sensitivity exhibited solely towards amikacin and vancomycin. Phylogenetic tree analysis confirmed that it was related to Rothia nasimurium strain E1706032 and Rothia sp.SD9660Na. The draft genome sequencing results showed that the total length of the gene was 2,387,685 bp, and the GC content was 59.35%. VFDB database analysis identified 112 annotated genes in Y1, including those related to bacterial adhesion, regulation, nutrient metabolism factors, hemolysin, immunomodulation, and iron uptake proteins. CARD database analysis showed that Y1 was resistant to a variety of antibiotics such as glycopeptides, tetracyclines, aminoglycosides and polypeptides. Animal pathogenicity tests have shown that Y1 can cause lung damage, coat loss and skin inflammation. This study revealed a series of virulence and drug resistance genes and pathogenicity of Y1. The results of this study have important reference value for prevention and treatment of Rothia infection in the future.
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